Effect of Non-Insulin Dependent Diabetes on Cyclosporin A Disposition in Goto-Kakizaki (GK) Rats
スポンサーリンク
概要
- 論文の詳細を見る
We previously reported that the pharmacokinetics of cyclosporin A (CyA), particularly absorption, were altered in diabetic rats treated with streptozotocin. In the present study, the effect of diabetes on pharmacokinetics of CyA after intravenous and oral administration of CyA using the blood and lymph and the gastrointestinal transit were examined in Goto-Kakizaki (GK) rats, a genetic model of non-obese non-insulin-dependent diabetes mellitus (NIDDM), and compared to non-diabetic Wistar rats. Although the systemic and lymphatic availability after intravenous administration of CyA to the GK rats was not significantly different from those of the control Wistar rats, those availability after oral administration of CyA to GK rats was markedly reduced in comparison. These results suggest that the pharmacokinetics of CyA, particularly absorption, was altered in GK rats. Studies on the gastrointestinal transit in GK rats showed that the gastric emptying rate was lower than that of Wistar rats, suggesting that a change in gastrointestinal transit in GK rats may influence the absorption of CyA. The gastric emptying rate in GK rats altered not only the systemic availability but also the lymphatic availability, suggesting that the altered systemic availability may cause adverse effects and that altered lymphatic availability may influence the immunosuppressive effects.
- 公益社団法人日本薬学会の論文
- 1997-09-15
著者
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TOYOTA Takayoshi
The Third Department of Internal Medicine, Tohoku University School of Medicine
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Toyota T
Third Department Of Internal Medicine Tohoku University School Of Medicine
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Toyota Takayoshi
東北大学 医系研究 消化器病態
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Ogata Masaki
Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Toyota T
Tohoku Rosai Hospital Sendai Jpn
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MURATA Ryo
First Department of Pharmaceutics, Tohoku Pharmaceutical University
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TOYOTA TAKAYOSHI
Tohoku Rosai Hospital
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Ogata Masaki
Department of Cardiology, Nagoya City University Medical School
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Ogata Masahiro
Faculty Of Pharmaceutical Sciences Aomori University
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Toyota Takayoshi
The Third Department Of Internal Medicine Tohoku University School Of Medicine
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Murata R
First Department Of Pharmaceutics Tohoku Pharmaceutical University
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Murata Ryo
Department Of Pharmaceutics Tohoku College Of Pharmacy
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Ogata Masaki
Department Of Cardiology Nagoya City University Medical School
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Ogata Masaki
Laboratory Of Bioorganic Chemistry School Of Pharmaceutical Sciences University Of Shizuoka
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UCHIMURA Takashi
Department of Pharmaceutics, Tohoku College of Pharmacy
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IIZUKA Yukisumi
Department of Pharmaceutics, Tohoku College of Pharmacy
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SUZUKI Susumu
The Third Department of Internal Medicine, Tohoku University School of Medicine
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HIKICHI Noboru
Department of Pharmaceutics, Tohoku College of Pharmacy
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Uchimura T
Department Of Pharmaceutics Tohoku College Of Pharmacy
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Uchimura Takashi
Department Of Biological Science Graduate School Of Science Hiroshima University
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Iizuka Y
Department Of Pharmaceutics Tohoku College Of Pharmacy
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Iizuka Yukisumi
Department Of Pharmaceutics I Tohoku College Of Pharmacy
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Ogata M
Laboratory Of Bioorganic Chemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Hikichi N
Department Of Pharmaceutics I Tohoku College Of Pharmacy
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Hikichi Noboru
Department Of Pharmaceutics Tohoku College Of Pharmacy
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Suzuki Susumu
The Third Department Of Internal Medicine Tohoku University School Of Medicine
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HIKICHI Noboru
Department of Pharmaceutics I, Tohoku College of Pharmacy
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TOYOTA Takayoshi
The Third Department of Internal Medicine and The Department of Psychosomatic Medicine, Tohoku University School of Medicine,
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