Protein Kinase C Activation by Iridal Type Triterpenoids
スポンサーリンク
概要
- 論文の詳細を見る
Eleven iridal type triterpenoids from Iris tectorum and Belamcanda chinensis were examined for protein kinase C (PKC) activation and binding activity to PKC. Among the tested compounds, nine iridals showed dose dependent activities, and a mutual relation between the two activities was also observed. 28-Deacetylbelamcandal, which has been found to be a new class 12-O-tetradecanoylphorbol 13-acetate type tumor promoter, showed the most potent activity in both tests. The structural requirements of the iridals inducing these activities were as follows: 1) a hydrophobic side-chain, 2) an E-methylidene aldehyde group at the C-1 position, and 3) a hydroxyl group at the C-26 position.
- 公益社団法人日本薬学会の論文
- 2002-04-01
著者
-
TAKAHASHI Kunihiko
Saitama Institute of Public Health
-
Hano Yoshio
Faculty Of Pharmaceutical Sciences Toho University
-
Nomura Taro
Faculty Of Pharmaceutical Science Toho University
-
SUZUKI Sumiko
National Institute of Public Health
関連論文
- 組織化学的手法を用いた遺伝子組換えパパイヤ(55-1)検知法の確立
- New Qualitative Detection Methods of Genetically Modified Potatoes(Highlighted paper selected by Editor-in-chief)(Analytical Biochemistry)
- Phenolic Constituents of Glycyrrhiza Species. 19 : Phenolic Constituents of Aerial Parts of Glycyrrhiza eurycarpa
- Mechanistic Aspects of Green Tea as a Cancer Preventive : Effect of Components on Human Stomach Cancer Cell Lines
- Structure of New Cyclic Depsipeptides, Bu-2841-08 and-10
- PA32 ABSOLUTE STRUCTURE OF OPTICALLY ACTIVE DIELS-ALDER TYPE ADDUCTS FROM THE MORUS ROOT BARK
- A New Matrix System in Fast Atom Bombardment Mass Spectrometry of Prenylated- and Geranylated-Phenolic Compounds
- Studies on Fast Atom Bombardment(FAB), Electron Ionization (EI) and Chemical Ionization(CI) Mass Spectra of Prenylated Flavonoids
- Tandem Mass Spectrometric Study on Fragmentation in Fast Atom Bombardment Mass Spectra of Prenylated Flavonoids
- E-9-2 On the Structure of Ramanone(Steroids)
- Phenolic Constituents of the Root Bark of Chinese Morus australis
- Molecular Ion M+· Formation under Fast-atom Bombardment Conditions Using Protic and Aprotic Liquid Matrices
- Chemistry and biosynthesis of isoprenylated flavonoids from Japanese mulberry tree
- Protein Kinase C Activation by Iridal Type Triterpenoids
- PA29 ON THE STRUCTURES OF RED PIGMENTS AND THE RELATED COMPOUNDS FROM THE MORUS ROOT BARK
- Phenolic Constituents of Glycyrrhiza Species. 19 : Phenolic Constituents of Aerial Parts of Glycyrrhiza eurycarpa
- Phenolic Constituents of the Root Bark of Chinese Morus australis
- Phenolic Constituents of Glycyrrhiza Species. 11 : A New Prenylated 3-Arylcoumarin, Gancaonin W, from Licorice
- Studies on Morus bombycis callus cultures
- Phenolic Constituents of Glycyrrhiza Species. 17 : Three Isoprenoid-Substituted Isoflavans, Gancaonins X-Z, from Chinese Folk Medicine "Tiexin Gancao" (Root Xylems of Glycyrrhiza Species)