Testicular Toxicity of Rinbacin in Rats

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概要

• 論文の詳細を見る

• Rinbacin is a local Nigerian herbal remedy. The effects of rinbacin on testicular histology were studied in prepubertal rats. Sexually immature male rats, divided into seven per group, were given rinbacin in drinking waters at 0, 26.25g/l, or 52.50g/l for 13 weeks, after which the animals were killd and testes excised, weighed, and processed for histologic study. The epididymal sperm number(ESN)was determined. There were no significant effects of either the low or high doses of rinbacin on fluid intake, body weight, testicular weight, and testis-body weight ratio. There was, however, a significant(p<0.05)decrease in the ESN of animals at both doses of rinbacin. Histologic examination of the testes indicated that the high dose of rinbacin induced significant degenerative changes, while the low dose had only a mild effect on testicular histology. Rinbacin decreases the ESN and causes degenerative lesions, especially at the high dose, in prepubertal rats.

• 公益社団法人日本薬学会の論文
• 2002-02-01

著者

• Afonne Onyenmechi

  Toxicology Unit Department Of Pharmacology Nnamdi Azikiwe University Nnewi Campus

• Afonne Onyenmechi

  Department Of Pharmacology College Of Health Sciences Nnamdi Azikiwe University

• Orisakwe O

  Toxicology Unit Department Of Pharmacology Nnamdi Azikiwe University Nnewi Campus

• Orisakwe Orish

  Department Of Pharmacology College Of Health Sciences Nnamdi Azikiwe University

• Afonne Onyenmechi

  Departments Of Pharmacology College Of Health Sciences Nnamdi Azikiwe University Nnewi Campus

• Agbasi Patrick

  Departments of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus

• DIOKA Chudi

  Chemical Pathology, College of Health Schiences, Nnamdi Azikiwe University, Nnewi Campus

• AZIKIWE Chukwuemeka

  Chemical pathology, College of Health Schiences, Nnamdi Azikiwe University, Nnewi Campus

• OBI Ejeatuluchukwu

  Haematology, College of Health Schiences, Nnamdi Azikiwe University, Nnewi Campus

• Dioka C

  Department Of Chemical Pathology College Of Health Sciences Nnamdi Azikiwe University Nnewi Campus

• Agbasi Patrick

  Departments Of Pharmacology College Of Health Sciences Nnamdi Azikiwe University Nnewi Campus

• Agbasu Patrick

  Biokinetic Research Group Toxicology Unit Deparment Of Pharmacology College Of Health Science Nnamdi

• Obi Ejeatuluchukwu

  Toxicology Unit Department Of Pharmacology Nnamdi Azikiwe University Nnewi Campus

• Azikiwe Chukwuemeka

  Chemical Pathology College Of Health Schiences Nnamdi Azikiwe University Nnewi Campus

• Afonne Onyemnechi

  Departments of Phaemancology, College of Health Schiences, Nnamdi Azikiwe University, Nnewi Campus

関連論文

• Investigation into the Haematologic and Hepatotoxic Effects of Rinbacin in Rats
• Effects of Rinbacin Extract on Rat Kidney
• Testicular Toxicity of Rinbacin in Rats
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