Zinc Protection of Mercury-Induced Hepatic Toxicity in Mice

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概要

• 論文の詳細を見る

• The actions and interactions of heavy metals on certain organ function have been of concern, since occupational exposure to certain metals results in impairment of functions, Studies were carried out to determine the effects of zinc (Zn) and mersury (Hg) on murine liver. CD-1 male mice were administered 4 ppm HgCl_2,800 ppm ZnCl_2,4 ppm HgCl_2+800 ppm ZnCl_2 or deionized water in their drinking water for 12 weeks. Histological evaluation of the liver confirmed the toxic effects of Hg, as well as the normal morphology of the Zn-exposed animals. A combined treatment of both metals resulted in protection of the Hg-induced liver damage by Zn. The results of this experiment indicate that Hg has a toxic effect on liver, while Zn has a protective action against such toxic effects.

• 公益社団法人日本薬学会の論文
• 2000-03-01

著者

• Afonne Onyenmechi

  Department Of Pharmacology College Of Health Sciences Nnamdi Azikiwe University

• Orisakwe Orish

  Department Of Pharmacology College Of Health Sciences Nnamdi Azikiwe University

• Ilondu Ndidi

  Department Of Pharmacology College Of Health Sciences Nnamdi Azikiwe University

• NDUBUKA Gideon

  Anambra State, Nigeria, Department of Pathology, Abia State University

• Ndubuka Gideon

  Anambra State Nigeria Department Of Pathology Abia State University

関連論文

• Investigation into the Haematologic and Hepatotoxic Effects of Rinbacin in Rats
• Effects of Rinbacin Extract on Rat Kidney
• Testicular Toxicity of Rinbacin in Rats
• Zinc Protection of Mercury-Induced Hepatic Toxicity in Mice

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