TRANS-PROSTAGLANDIN E_2 ENHANCES FIBRINOLYSIS

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概要

• 論文の詳細を見る

• 5,6-trans-Prostaglandin E_2 (trans-PG E_2) was found to accelerate the fibrinolysis in a cell-free system. trans-PG E_2 decreased the lysis time by 15% in the fibrin clot lysis time method and increased the lysis area by 22% in the fibrin plate method. On the contrary, 5,6-cis-prostaglandin E_2 did not have such effects. trans-PG E_2 did not exert the effect in the absence of either tissue-plasminogen activator or plasminogen. These results suggest that trans-PG E_2 enhances the generation of plasmin from plasminogen by tissue-plasminogen activator.

• 公益社団法人日本薬学会の論文

著者

• Urano Tsutomu

  Department Of Public Health School Of Pharmaceutical Sciences Kitasato University

• Urano T

  Department Of Analytical Chemistry School Of Pharmaceutical Sciences Kitasato University

• Urano Tsutomu

  Department Of Analytical Chemistry School Of Pharmaceutical Sciences Kitasato University

• Kinoshita Toshio

  Department of Electronic Device Engineering, Graduate School of Information Science and Electrical E

• SHIMOKAWA Mari

  Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kitasato University

• Shimokawa Mari

  Department Of Analytical Chemistry School Of Pharmaceutical Science Kitasato University

• Kinoshita Toshio

  Department Of Analytical Chemistry School Of Pharmaceutical Science Kitasato University

• KINOSHITA Toshio

  Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kitasato University

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