Inhibition of Intestinal α-Glucosidase and Postprandial Hyperglycemia by N-Substituted Moranoline Derivatives

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概要

• 論文の詳細を見る

• The inhibitory activity of N-substituted derivatives of moranoline (1-deoxynojirimycin) against intestinal α-glucosidase and postprandial hyperglycemia was evaluated. None of the N-substituted derivatives studied displayed more potent inhibition of sucrase or maltase from rabbit intestines than the parent compound moranoline. However, unlike the in vitro results, many compounds exhibited more potent hypoglycemic activities than moranoline in sucrose-, or starch-loaded rat models. Alkenyl or aralkenyl derivatives displayed more potent hypoglycemic activities than alkyl or aralkyl derivatives. There was a weak correlation between in vitro and in vivo assay systems found by statistical analysis. It is necessary to evaluate compounds in vivo in order to select the most potent hypoglycemic compound.

• 公益社団法人日本薬学会の論文

著者

• Enomoto Hiroshi

  Research and Development Center, Santen Pharmaceutical Co., Ltd.

• YOSHIKUNI YOSHIAKI

  Reseach Laboratories, Nippon Shinyaku Co. Ltd.

• Yoshikuni Yoshiaki

  Reseach Laboratories Nippon Shinyaku Co. Ltd.

• Ezure Yohji

  Research Laboratories Nippon Shinyaku Co. Ltd.

• Enomoto H

  Showa Coll. Pharmaceutical Sciences Tokyo Jpn

• AOYAGI Yoshiaki

  Research Laboratories, Nippon Shinyaku Co., Ltd.

• Yoshikuni Y

  Nippon Shinyaku Co. Ltd. Kyoto Jpn

• Aoyagi Yoshiaki

  Research Laboratories Nippon Shinyaku Co. Ltd.

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