Metabolism of Diltiazem. I. Structures of New Acidic and Basic Metabolites in Rat, Dog and Man
スポンサーリンク
概要
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The metabolites of diltiazem in the urine of rats, dogs and man and rat bile were investigated. New metabolites including six acidic metabolites (A1-A6) and four basic metabolites (M9,MB, MC, MD) were isolated by high performance liquid chromatography and their structures were characterized by gas chromatography-mass spectrometry. Acidic metabolites A1,A2,A3,A4 and basic metabolite MD identified by comparing their properties with the synthetic compounds ; (+)-(2S, 3S)-2-(4-methoxyphenyl)-3-acetoxy-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-5-acetic acid (A1), 3-deacetyl-A1 (A2), O-demethyl-A1 (A3), O-demethyl-3-deacetyl-A1 (A4) and N-didemethyl-diltiazem (MD). All acidic metabolites have a CH_2COOH group which may be formed by oxidative deamination of the CH_2CH_2N (CH_3)_2 group of diltiazem.
- 公益社団法人日本薬学会の論文
著者
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Ito Yutaka
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
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Suzuki T
Departments Of Biopharmaceutice Graduate School Of Pharmaceutical Sciences Chiba University
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Usuki S
Biological Research Laboratory : Organic Chemistry Research Laboratory : Tanabe Seiyaku Co. Ltd.
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SUGAWARA Yoichi
Biological Research Laboratory, Tanabe Seiyaku Co. Ltd.
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NAKAMURA Susumu
Biological Research Laboratory, Tanabe Seiyaku Co. Ltd.
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OHASHI Motoaki
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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USUKI Satoshi
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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SUZUKI Tatsuo
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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HARIGAYA Shoichi
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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KUME Toshiyuki
Biological Research Laboratory
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NAKAO Akio
Biological Research Laboratory
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GAINO Mitsunori
Biological Research Laboratory
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INOUE Hirozumi
Biological Research Laboratory
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Nakamura Susumu
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
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Usuki Satoshi
Biological Research Laboratory : Organic Chemistry Research Laboratory : Tanabe Seiyaku Co. Ltd.
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Nakao Akio
Biological Research Laboratory : Organic Chemistry Research Laboratory : Tanabe Seiyaku Co. Ltd.
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Ohashi M
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Ohashi M
Tanabe Seiyaku Co. Ltd. Saitama Jpn
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Inoue H
Biological Research Laboratory : Organic Chemistry Research Laboratory : Tanabe Seiyaku Co. Ltd.
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Kume Toshiyuki
Biological Research Laboratory : Organic Chemistry Research Laboratory : Tanabe Seiyaku Co. Ltd.
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Harigaya S
Biological Research Laboratory : Organic Chemistry Research Laboratory : Tanabe Seiyaku Co. Ltd.
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Suzuki Tsuguyoshi
Departments Of Biopharmaceutice Graduate School Of Pharmaceutical Sciences Chiba University
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Sugawara Yoichi
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
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Gaino Mitsunori
Biological Research Laboratory : Organic Chemistry Research Laboratory : Tanabe Seiyaku Co. Ltd.
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HARIGAYA Shoichi
Biological Research Laboratory : Organic Chemistry Research Laboratory : Tanabe Seiyaku Co., Ltd.
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