THE IMMUNOSUPPRESSIVE EFFECTS OF TRICHOTHECENES AND CYCLOCHLOROTINE ON THE ANTIBODY RESPONSES IN GUINEA PIGS

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概要

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• Immunosuppressive effects of trichothecenes of Fusarium solani and Fusarium nivale, T-2 toxin and fusarenon-X, and also of a mycotoxin of Penicillium islandicum, cyclochlorotine, were studied by measuring the anti-2,4-dinitrophenyl (DNP) antibody responses in guinea pigs immunized with DNP-bovine serum albumin. Among these mycotoxins, T-2 toxin alone suppressed strongly the anti-DNP antibody responses at a certain sublethal dose. With other mycotoxins, no effect was observed at any sublethal doses tested. All of the mycotoxins, on the other hand, inhibited the in vitro blast transformation of guinea pig splenic cells stimulated with lipopolysaccharide of Escherichia coli (B cell mitogen) or concanavalin A (T cell mitogen), when measured by incorporation of ^3H-thymidine into DNA. Their inhibitory activities were independent of the sort of mitogen used. As in the case of the antibody responses, T-2 toxin was most potent in reducing the DNA synthesis, and exhibited about 10 and 1000 times as potent inhibitory activity as fusarenon-X and cyclochlorotine, respectively.

• 公益社団法人日本薬学会の論文

著者

• Ito Hiromichi

  Department Of Pediatrics Institute Of Health Biosciences University Of Tokushima Graduate School

• Koyama Jiro

  Department Of Electronics Faculty Of Engineering Osaka University

• Watanabe Kyoko

  Department of Pediatric Dentistry, Osaka Dental University

• Koyama Jiro

  Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine

• Ito Hiromichi

  Department Of Anesthesiology And Clinical Physiology Tokyo Medical And Dental University Graduate Sc

• Watanabe Kyoko

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokkaido University

• Watanabe Kyoko

  Department Of Basic Space Science Japan Aerospace Exploration Agency

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