IMPROVEMENT OF DIABETIC SYMPTOMS OF HEREDITARY DIABETIC (KK) MICE BY A SINGLE INJECTION WITH ISLETACTIVATING PROTEIN (IAP)

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概要

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• Islet-activating protein (IAP) prepared from the culture medium of Bordetella pertussis cells was very effective in eliminating diabetic symptoms characteristic of hereditary diabetic KK mice over a long period of time. After a single injection of IAP (5 μg/kg body wt) into KK mice, the non-fasting concentration of blood glucose was maintained nearly normal over 2 weeks, with a gradual return to the pre-IAP level 30 days later. During this period, glucose tolerance was normalized and only few animals excreted glucose in urine. The second injection of IAP to these diabetic mice caused a more prolonged restoration of normoglycemia. When KK mice had been injected with IAP, they responded to epinephrine and isoproterenol more readily than did ddY mice in increasing plasma insulin and glycerol.

• 公益社団法人日本薬学会の論文

著者

• Ui Michio

  Department Of Physiological Chemistry Faculty Of Pharmaceutical Science Hokkaido University.

• Ui Michio

  Department Of Physiological Chemistry Faculty Of Medicine And Pharmaceutical Sciences University Of

• Okamoto Taira

  Shiga Laboratory Kakenyaku Kako Co. Ltd.

• Yajima Motoyuki

  Shiga Laboratory Kakenyaku Kako Co. Ltd.

• ITOH AKIRA

  Shiga Laboratory, Kakenyaku Kako Co. Ltd.

• Itoh Akira

  Shiga Laboratory Kakenyaku Kako Co. Ltd.

• UI MICHIO

  Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University School of Medicine

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