ENHANCED PERIPHERAL GLUCOSE UTILIZATION AND SUPPRESSED HEPATIC GLYCOGEN SYNTHESIS IN KK MICE TREATED WITH ISLET-ACTIVATING PROTEIN (IAP)

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概要

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• Effect of islet-activating protein (IAP) on glucose utilization of peripheral tissues and glycogen synthesis of the liver was investigated in diabetic KK mice. The ^<14>C-content of diaphragm glycogen following the injection of [U-^<14>C] glucose was much less in KK mice than in dd/Y mice, and it was restored to normal in KK mice treated with IAP. The enhanced glucose utilization in these mice was completely abolished by the injection of anti-insulin serum. Glycogen synthesis of the liver after glucose load was also less in KK mice than in dd/Y mice, and it was clearly suppressed in both groups of mice by IAP treatment. It was concluded that improved glucose tolerance of IAP-treated KK mice was mostly due to enhanced glucose utilization of peripheral tissues secondary to increased insulin secretion induced by IAP injection.

• 公益社団法人日本薬学会の論文

著者

• Okamoto Taira

  Shiga Laboratory Kakenyaku Kako Co. Ltd.

• Yajima Motoyuki

  Shiga Laboratory Kakenyaku Kako Co. Ltd.

関連論文

• IMPROVEMENT OF DIABETIC SYMPTOMS OF HEREDITARY DIABETIC (KK) MICE BY A SINGLE INJECTION WITH ISLETACTIVATING PROTEIN (IAP)
• ENHANCED PERIPHERAL GLUCOSE UTILIZATION AND SUPPRESSED HEPATIC GLYCOGEN SYNTHESIS IN KK MICE TREATED WITH ISLET-ACTIVATING PROTEIN (IAP)
• SPECIES DIFFERENCES IN ACTIONS OF ISLET-ACTIVATING PROTEIN, PERTUSSIS TOXIN

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