INTERFERON INDUCING ACTIVITY OF A 2'-MODIFIED DOUBLESTRANDED COMPLEX, POLY (2'-AZIDO-2'-DEOXYINOSINIC ACID) POLY (CYTIDYLIC ACID)

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Although the presence of free 2'-hydroxyl groups in both strands of a double-stranded RNA complex has been recognized as one of the major requisites for the interferon inducing activity of double-stranded RNAs, we have found a particular analog of (I)_n・(C)_n, in which the 2'-hydroxyls of the purine strand were replaced by azido groups [(dIz)_n・(C)_n], to be exquisitely effective in inducing interferon. Various other 2'-azido analogs, i.e. (dIz)_n・(brC)_n, (I)_n・(dCz)_n, (dAz)_n・(U)_n, (dAz)_n・(rT)_n and (dAz)_n・(dUz)_n were inactive as inducers of interferon. Thus we come to the conclusion that the interferon inducing system recognizes total threedimensional conformation of the double-stranded RNA.
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