Studies on the Surface Anesthetic Activity of Bufadienolides Isolated from Ch'an Su
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概要
- 論文の詳細を見る
The surface anesthetic activities of ten bufadienolides, i. e., resibufogenin, bufalin, bufotalin, desacetyl-bufotalin, cinobufagin, desacetyl-cinobufagin, cinobufotalin, desacetyl-cinobufotalin, telocinobufagin and marinobufagin, were studied using the guinea pig cornea. With exceptions of resibufogenin and marinobufagin, all substances tested were more effective than cocaine. Their anesthetic activities were in the following order : bufalin > telocinobufagin > bufotalin > cinobufagin > cinobufotalin > desacetyl-bufotalin ≨ desacetyl-cinobufagin ≨ desacetyl-cinobufotalin. Resibufogenin and marinobufagin had no appreciable effect on the cornea. There is some correlation between the chemical structure and the surface anesthetic activity in the bufadienolides tested.
- 公益社団法人日本薬学会の論文
- 1976-08-25
著者
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酒井 健
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Chiba
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釜野 徳明
Cencer Reseach Institute And Department Of Chemistry Arizona State University
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吉田 誠一郎
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Chiba
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釜野 徳明
Department of Chemistry, Arizona State University
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