Rhinovirus Inhibition by Bufadienolides

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概要

• 論文の詳細を見る

• An evaluation of thirty-four bufadienolides and two related cardenolides against a series of rhinoviruses in vitro has been completed. Most of the bufadienolides were found to display some inhibitory activity. Scillarenin and 3-O-[N-(tert-butoxycarbonyl)hydrazido]succinylbufalin were found to be the most active with chemotherapeutic indices of 32 and 16,respectively. In general, the 14β-hydroxy-bufadienolides showed the strongest antiviral activity, and were found more toxic than the corresponding 14β, 15β-epoxy-bufadienolides. Introduction of a 16β-hydroxy or 16β-acetoxy substituent into the 14β, 15β-epoxybufadienolides enhanced their antiviral activity. Substituents at the 3β-, 5β-, and 19-positions appeared to affect only the level of toxicity.

• 公益社団法人日本薬学会の論文
• 1988-01-25

著者

• 釜野 徳明

  Cencer Reseach Institute And Department Of Chemistry Arizona State University

• 佐藤 統夫

  Cencer Reseach Institute And Department Of Chemistry Arizona State University

• Pettit George

  Cencer Reseach Institute And Department Of Chemistry Arizona State University

• 仲吉 洋

  Cencer Reseach Institute and Department of Chemistry, Arizona State University

• SMITH CECIL

  Cencer Reseach Institute and Department of Chemistry, Arizona State University

• Smith Cecil

  Cencer Reseach Institute And Department Of Chemistry Arizona State University

• 仲吉 洋

  Cencer Reseach Institute And Department Of Chemistry Arizona State University

関連論文

• Studies on Topical Antiinflammatory Corticosteroids. III. : Synthesis and Vasoconstrictive Activity of 11β, 17α, 21-Trihydroxy-2'-phenyl-2'H-2,4-pregnadieno[3,2-c]pyrazol-20-one Derivatives
• Studies on Topical Antiinflammatory Corticosteroids. II. : Synthesis and Vasoconstrictive Activity of 11β, 17α, 21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione 17-Methoxy- and (Methylthio)acetates
• Studies on Topical Antiinflammatory Corticosteroids. I. Syntheses and Vasoconstrictive Activities of 11β, 17α, 21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione 17-Ester and 17,21-Diester Derivatives
• Rhinovirus Inhibition by Bufadienolides
• Bufadienolides. XX. 14β-Chloro-bufadienolides
• Studies on the Surface Anesthetic Activity of Bufadienolides Isolated from Ch'an Su
• Bufadienolides. VII. Ring-Opening Reaction of 14,15-α, β-Epoxides with Hydroiodic Acid

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