Effect of Bufalin on Acetylcholine Levels in Rat Brain : Relation to Its CNS-Stimulating Action

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概要

• 論文の詳細を見る

• 1. Total acetylcholine (ACh) levels in the rat whole brain homogenate decreased during the maximal tonic extension induced by bufalin. 2. "Free" ACh levels in the rat whole brain homogenate increased during the maximal tonic extension induced by bufalin, but not by pentylenetetrazol. 3. ACh release from rat cerebral cortical slices increased in a medium containing bufalin. 4. After intracerebral Hemicholinium-3 or scopolamine, 50% convulsive dose of bufalin in mice was increased, but was decreased after eserine. 5. A relationship between the convulsant effect of bufalin and its ACh-releasing effect was discussed.

• 公益社団法人日本薬学会の論文
• 1977-01-25

著者

• 酒井 健

  Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Chiba

• 吉田 誠一郎

  Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Chiba

関連論文

• Effect of Bufalin on Acetylcholine Levels in Rat Brain : Relation to Its CNS-Stimulating Action
• Studies on the Surface Anesthetic Activity of Bufadienolides Isolated from Ch'an Su

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