Syntheses of 3,4-Dihydro-2H-pyridazino [4,5-b]-1,4-thiazin-8 (7H)-one and -5 (6H)-one
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概要
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Two novel fused ring systems made up of 1,4-thiazine and 3 (2H)-pyridazinone were synthesized. 3,4-Dihydro-7-methyl-2H-pyridazino [4,5-b]-1,4-thiazin-8 (7H)-one was obobtained from the intramolecular cyclization of 4-chloro-5-(2-chloroethylamino)-2-methyl-3 (2H)-pyridazinone with sodium sulfide. An isomer, 3,4-dihydro-6-methyl-2H-pyridazino-[4,5-b]-1,4-thiazin-5 (6H)-one, was directly afforded by the condensation of 4,5-dichloro-2-methyl-3 (2H)-pyridazinone with sodium 2-aminoethanthiolate.
- 公益社団法人日本薬学会の論文
- 1982-03-25
著者
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柳沼 英哉
Faculty of Pharmaceutical Sciences, Osaka University
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松尾 俊康
Research Laboratories, Morishita Pharmaceutical Co., Ltd.
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塚本 善次
Research Laboratories, Morishita Pharmaceutical Co. Ltd.
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高木 隆
Research Laboratories, Morishita Pharmaceutical Co. Ltd.
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高木 隆
Research Laboratories Morishita Pharmaceutical Co. Ltd.
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柳沼 英哉
Research Laboratories, Morishita Pharmaceutical Co., Ltd.,
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松尾 俊康
Research Laboratories Morishita Pharmaceutical Co. Ltd.
-
塚本 善次
Research Laboratories Morishita Pharmaceutical Co. Ltd.
-
柳沼 英哉
Faculty Of Pharmaceutical Sciences Osaka University
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柳沼 英哉
Research Laboratories Morishita Pharmaceutical Co. Ltd.
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