Chemical and Kinetic Study on Stabilities of 3-Morpholinosydnonimine and Its N-Ethoxycarbonyl Derivative
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概要
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Stabilities of 3-morpholinosydnonimine (II), hydrochloride (I) and N-ethoxycarbonyl-3-morpholinosydnonimine (VIII) were examined by photometry, potentiometry, thin-layer chromatography and spectroscopy. In alkaline solution VIII goes to ethanol, carbon dioxide and II, which successively decomposes to N-morpholino-N-nitrosoaminoacetic acid (V) and N-cyanomethylenaminomorpholine (VI) via N-morpholino-N-nitrosoaminoacetonitrile (III). In the processes of I⇋II⇀III, the initial equilibrium is very rapid and the consecutive cleavage is a spontaneous first order reaction at pH 3-7 or a base catalyzed reaction at pH 8-10. The initial process of VIII&rharuII is a base catalyzed first order hydrolysis of N-ethoxycarbonyl group. Hydrolyses of I and VII in hydrochloric acid form morpholine, nitrogen, chloroacetic acid and ammonium chloride. Photolyses of I and VII in acid solution at λ<320 mμ give glycolic acid beside the products mentioned above. Formation of I from III and hydrolysis of VI to N-aminomorpholine are acid catalyzed pseudo-first-order reactions. Decomposition of III to VI seems to be a radical reaction.
- 公益社団法人日本薬学会の論文
- 1971-06-25
著者
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朝日 豊
Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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篠崎 一夫
Central Research Division Takeda Chemical Industries Ltd.
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篠崎 一夫
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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永岡 道代
Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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朝日 豊
Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.:(present Ad
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永岡 道代
Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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