4-(3,4-Dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline Derivatives. II.Their Renal Vasodilation Activity and Structure-Activity Relationship
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概要
- 論文の詳細を見る
A series of 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline derivatives showed potent DA_1 agonistic activities. We investigated the structure-activity relationship of the racemic compounds of this series. 4-(3,4-Dihydroxyphenyl)-7-methanesulfonamido-1,2,3,4-tetrahydroisoquinoline (43) was identified as a potent renal vasodilator with activity almost equal to that of YM435 (1).
- 公益社団法人日本薬学会の論文
- 1996-10-15
著者
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TANAKA Akihiro
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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ANAN Hideki
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,
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YATSU Takeyuki
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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Yatsu Takeyuki
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Tanaka Akihiro
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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TSUZUKI Ryuji
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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Anan Hideki
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Tsuzuki Ryuji
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Yokota Masaki
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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FUJIKURA Takashi
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,
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Fujikura Takashi
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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