Studies on Pyridonecarboxylic Acids. IV. Synthesis and Antibacterial Activity Evaluation of S-(-)- and R-(+)-6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic Acids
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概要
- 論文の詳細を見る
Optically active isomers of 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid (NM394,3) were prepared through optical resolution of their racemic intermediate (±)-1 by high-performance liquid chromatography (HPLC). The absolute configuration at the C-1 position in the thiazetoquinolone ring of (-)-3 was confirmed by X-ray analysis of (-)-4 to be S. The in vitro antibacterial activity of (-)-3 was 2-8 times that of (+)-3.
- 公益社団法人日本薬学会の論文
- 1995-07-15
著者
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冨井 由文
日本新薬株式会社創薬第二研究所
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北野 正彦
Chemistry Laboratories And Biology Laboratories Nippon Shinyaku Company Ltd.
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数野 憲二
Chemistry Laboratories And Biology Laboratories Nippon Shinyaku Company Ltd.
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Kazuno Kenji
Chemistry Laboratories And Biology Laboratories Nippon Shinyaku Company Ltd.
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松田 真人
日本新薬株式会社創薬第二研究所
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尾崎 正邦
日本新薬株式会社創薬第二研究所
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黄瀬 正博
日本新薬株式会社創薬第二研究所
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瀬川 純
Chemistry Laboratories and Biology Laboratories, Nippon Shinyaku Company, Ltd.,
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松岡 正人
Chemistry Laboratories and Biology Laboratories, Nippon Shinyaku Company, Ltd.,
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網本 功
Chemistry Laboratories and Biology Laboratories, Nippon Shinyaku Company, Ltd.,
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尾崎 正邦
Chemistry Laboratories and Biology Laboratories, Nippon Shinyaku Company, Ltd.,
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松田 真人
Chemistry Laboratories and Biology Laboratories, Nippon Shinyaku Company, Ltd.,
-
冨井 由文
Chemistry Laboratories and Biology Laboratories, Nippon Shinyaku Company, Ltd.,
-
黄瀬 正博
Chemistry Laboratories and Biology Laboratories, Nippon Shinyaku Company, Ltd.,
-
松岡 正人
Chemistry Laboratories And Biology Laboratories Nippon Shinyaku Company Ltd.
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冨井 由文
Research Laboratories Nippon Shinyaku Co. Ltd.
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Kise M
Chemistry Laboratories And Biology Laboratories Nippon Shinyaku Company Ltd.
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瀬川 純
Chemistry Laboratories And Biology Laboratories Nippon Shinyaku Company Ltd.
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網本 功
Chemistry Laboratories And Biology Laboratories Nippon Shinyaku Company Ltd.
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