Studies of the Selective O-Alkylation and Dealkylation of Flavonoids. XIX. A Convenient Method for Synthesizing 3,5,6,7,8-Pentaoxygenated Flavones
スポンサーリンク
概要
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The methoxymethyl ethers of 6-hydroxy-5,7,8-trimethoxyflavones, which were derived from 2', 5'-dihydroxy-3', 4', 6'-trimethoxyacetophenone, were oxidized with dimethyldioxirane to give the corresponding 3-hydroxyflavones. Selective O-alkylation and dealkylation of the 3-hydroxyflavones were examined and a convenient method for synthesizing the following ten kinds of 3,5,6,7,8-pentaoxygenated flavones was established : 3-hydroxy-5,6,7,8-tetramethoxyflavones, 3,5-dihydroxy-6,7,8-trimethoxyflavones, 3,6-dihydroxy-5,7,8-trimethoxyflavones, 3,5,6-trihydroxy-7,8-dimethoxyflavones, 3,5,6,7-tetrahydroxy-8-methoxyflavones, and their 3-methyl ethers. Furthermore, 3,5,8-trihydroxy-4', 6,7-trimethoxyflavone, 3,8-dihydroxy-4', 5,6,7-tetramethoxyflavone, and 5,8-dihydroxy-3,6,7-trimethoxyflavones were similarly synthesized and their spectral properties were examined. Additionally, the proposed structures of three natural flavones were revised.
- 1995-12-15
著者
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河村 保彦
Department of Applied Chemistry, Faculty of Engineering, Tokushima University
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河村 保彦
Department Of Chemical Science And Technology Faculty Of Engineering The University Of Tokushima
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堀江 徳愛
Department Of Applied Chemistry Faculty Of Engineering Tokushima University
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山下 和代
Department Of Chemical Science And Technology Faculty Of Engineering The University Of Tokushima
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山本 仁司
Department of Chemical Science and Technology, Faculty of Engineering, The University of Tokushima
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山本 仁司
Department Of Chemical Science And Technology Faculty Of Engineering The University Of Tokushima
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堀江 徳愛
Department of Chemical Science and Technology, Faculty of Engineering, The University of Tokushima
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