Retention Properties of Poly(carboxylic acid) Resin Column for High-Performance Liquid Chromatography

概要

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Maleic anhydride was copolymerized with divinylbenzene by suspension polymerization, and the spherical beads obtaiend (10-30 μm in diameter) were then hydrolyzed to a carboxylic acid (CA) resin. This CA resin had a low exchange capacity (0.40 meq/g), and was proposed to be useful as a packing material for high-performance liquid chromatography. The retention behavior of various compounds on a column packed with the CA resin was studied using methanol or a mixture of acetonitrile and buffer solution as the mobile phase. The acid-base and hydrophobic interactions, which occur because of the ionongenic and hydrophobic moieties of the CA resin, work effectively for the separation of the solutes. The CA resin column, with the appropriate selection of a mobile phase, is suggested to be useful for the separation of various kinds of solutes such as neutral, acidic and basic compounds.
公益社団法人日本薬学会の論文
1993-12-15