Research for New Antichagasic Drugs

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概要

• 論文の詳細を見る

• A series of ten 1-[(5-nitrothenylidene)amino]azoles has been synthesized by the reaction of 5-nitrothiophene-2-carbaldehyde with 1-aminopyrazole, 1-aminoimidazole, 1- and 4- amino-1,2,4-triazoles, 1-aminoindole, 1- and 2-aminoindazoles, 1-aminobenzimidazole and 1- and 2-aminobenzotriazoles. Physical data, spectroscopic characteristics and biological properties of all the derivatives have been examined. The antiprotozoal activity has been tested against Trypanosoma cruzi, comparative to Nifurtimox (Lampit).

• 公益社団法人日本薬学会の論文
• 1991-08-25

著者

• Elguero Jose

  Instituto De Quimica Medica Csic

• Elguero Jose

  Instituto De Quimica Medica

• MESTER Brenda

  Quimica Farmaceutica, Facultad de Quimica, Universidad de la Republica

• CLARAMUNT Rosa

  Dpto. Quimica Organica, Facultad de Ciencias

• ATIENZA Juan

  Dpto. de Parasitologia, Facultad de Farmacia, Universidad Complutense

• GOMEZ BARRIO

  Dpto. de Parasitologia, Facultad de Farmacia, Universidad Complutense

• ESCARIO Jose

  Dpto. de Parasitologia, Facultad de Farmacia, Universidad Complutense

• Atienza Juan

  Dpto. De Parasitologia Facultad De Farmacia Universidad Complutense

• Gomez Barrio

  Dpto. De Parasitologia Facultad De Farmacia Universidad Complutense

• Escario Jose

  Dpto. De Parasitologia Facultad De Farmacia Universidad Complutense

• Mester Brenda

  Quimica Farmaceutica Facultad De Quimica Universidad De La Republica

• Claramunt Rosa

  Dpto. Quimica Organica Facultad De Ciencias

関連論文

• Carbonic Anhydrase Activators. XV. A Kinetic Study of the Interaction of Bovine Isozyme II with Pyrazoles, Bis- and Tris-azolyl-methanse
• Synthesis of 3-(1-Adamantyl)pyrazole and 3,5-Di(1-adamantyl)pyrazole in a Microwave Oven
• Carbonic Anhydrase Activators. VII. Isozyme II Activation by Bisazolyl-methanes, -ethanes and Related Azoles
• Binuclear Pyrazoles. I. Synthesis and Cytotoxic Activity of 1,1'-Dibenzyl and 1,1'-Dihydroxymethyl 4,4'-Bispyrazoles
• Research for New Antichagasic Drugs
• Synthesis and Antifungal Properties of Some N, N'-Bis-azolylarylmethanes
• Aromatic systems with 10.PI. electrons derived from 3a-azapentalene. Part 40. Studies on the 1,2,4-triazolo(4,3-b)(1,2,4)triazole series.

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