Encapsulation of Drugs by Lyophilized, Empty Dipalmitoylphosphatidylcholine Liposomes
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概要
- 論文の詳細を見る
This study was concerned with whether drug-entrapping liposomes can be prepared by using lyophilized, empty dipalmitoylphosphatidylcholine (DPPC)-liposomes. It was found that drug-entrapping liposomes could be prepared by warming a mixture of lyophilized empty DPPC-liposomes and aqueous drug solution over the solid-liquid crystal phase-transition temperature (T_c), indicating that warming (>T_c) resealed the defect in the bilayer membranes after incorporation of the drug into the empty liposomes. The pharmaceutical potential of this new method was examined, and the results proved that drug-containing liposomes could be prepared readily or immediately before use, and with reproducibly high efficiency (40-70%) of entrapment.
- 公益社団法人日本薬学会の論文
- 1989-07-25
著者
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平野 耕一郎
塩野義製薬 中研
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平野 耕一郎
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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平野 耕一郎
Shionogi Research Laboratories Shionogi & Co. Ltd.
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地蔵本 博章
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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金岡 恵理
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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地蔵本 博章
塩野義製薬(株)中央研究所
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金岡 恵理
塩野義製薬 中研
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