Thromboxane A_2 Receptor Antagonists. III. : Synthesis and Pharmacological Activity of 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives with a Substituted Sulfonylamino Group at C-2

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概要

• 論文の詳細を見る

• Four stereoisomers of the title compounds based on side chain ring junctions, (+)-7a, (+)-7b, (-)-7c and (-)-24,were synthesized from (-)-myrtenol and (+)-nopinone. The (1R, 2R, 3S, 5S)-isomer (+)-7b had the most potent inhibitory activity against platelet aggregation and did not show partial agonist activity (shape change of platelets). We also synthesized the antipode, (-)-7b, and derivatives of (+)-7b with various kinds of substituents at the sulfonylamino group, 34a-n and p. The one-carbon homologated compound, (+)-58,was also prepared. The inhibitory activities of these compounds against platelet aggregation were measured.

• 公益社団法人日本薬学会の論文
• 1989-06-25

著者

• 萩下 山治

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 瀬野 薫

  Shionogi Research Laboratories, Shinogi & Co., Ltd.,

• 瀬野 薫

  Shionogi Research Laboratories Shionogi & Co. Ltd.

関連論文

• A Novel Class of Platelet Activating Factor (PAF) Antagonists. II. Modification of the 2-Position of the Glycerol Backbone of PAF-Sulfonamide Isosteres
• Synthesis and Absolute Configuration of (+)-threo-1-Hydroxy-2-(isopropylamino)-[10]-paracyclophane
• Thromboxane A_2 Receptor Antagonists. III. : Synthesis and Pharmacological Activity of 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives with a Substituted Sulfonylamino Group at C-2
• Thromboxane A_2 Receptor Antagonists. II. : Synthesis and Pharmacological Activity of 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives with the Benzenesulfonylamino Group
• Thromboxane A_2 Receptor Antagonists. I. : Synthesis and Pharmacological Activity of 7-Oxabicyclo-[2.2.1]heptane Derivatives with the Benzenesulfonylamino Group

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