Thromboxane A_2 Receptor Antagonists. II. : Synthesis and Pharmacological Activity of 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives with the Benzenesulfonylamino Group

スポンサーリンク

概要

• 論文の詳細を見る

• Various stereoisomers based on the α- and ω-side chain ring junctions of 6,6-dimethylbicyclo[3.1.1]heptane were synthesized. Their sodium salts 12,18,20,30 and 37 were examined in vitro for their inhibitory activity toward aggregation of rabbit platelet-rich plasma and rat washed platelets. Their potency was very high and the partial agonist effect was small. The differences of the side chain ring junctions did not affect the activity very much. Homologication in the ω-side chain (as in 47) decreased the activity.

• 公益社団法人日本薬学会の論文
• 1989-04-25

著者

• 萩下 山治

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 瀬野 薫

  Shionogi Research Laboratories, Shinogi & Co., Ltd.,

• 瀬野 薫

  Shionogi Research Laboratories Shionogi & Co. Ltd.

関連論文

• A Novel Class of Platelet Activating Factor (PAF) Antagonists. II. Modification of the 2-Position of the Glycerol Backbone of PAF-Sulfonamide Isosteres
• Synthesis and Absolute Configuration of (+)-threo-1-Hydroxy-2-(isopropylamino)-[10]-paracyclophane
• Thromboxane A_2 Receptor Antagonists. III. : Synthesis and Pharmacological Activity of 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives with a Substituted Sulfonylamino Group at C-2
• Thromboxane A_2 Receptor Antagonists. II. : Synthesis and Pharmacological Activity of 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives with the Benzenesulfonylamino Group
• Thromboxane A_2 Receptor Antagonists. I. : Synthesis and Pharmacological Activity of 7-Oxabicyclo-[2.2.1]heptane Derivatives with the Benzenesulfonylamino Group

スポンサーリンク