An Efficient Synthesis of 4-Acyl-5-hydroxy-3-methylisoxazoles through an Acyl-Transfer Reaction
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概要
- 論文の詳細を見る
Acylation of 3-methyl-3-isoxazolin-5-one (2a) with acyl chlorides was investigated. 2-Acyl-3-methyl-3-isoxazolin-5-ones 5 and 5-acyloxy-3-methylisoxazoles 6,which were prepared from 2a and acyl halides, underwent acyl-transfer reaction in the presence of 4-(N, N-dimethylamino)-pyridine or potassium carbonate to give 4-acyl-5-hydroxy-3-methylisoxazoles 4. By using this reaction, 4-(2,4-dichlorobenzoyl)-5-hydroxy-3-methylisoxazole (4h), which can be viewed as a bioisostere of the herbicidal compound, 4-(2,4-dichlorobenzoyl)-1,3-dimethyl-5-hydroxypyrazole (1a), was synthesized.
- 公益社団法人日本薬学会の論文
- 1986-08-25
著者
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上田 隆之
Agricultural Chemicals Research Laboratories Sankyo Co. Ltd.
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水貝 宗治
Agricultural Chemicals Research Laboratories, Sankyo Co., Ltd.
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佐藤 一雄
Agricultural Chemicals Research Laboratories, Sankyo Co., Ltd.
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佐藤 一雄
Agricultural Chemicals Research Laboratories Sankyo Co. Ltd.
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水貝 宗治
三共
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- ピラゾレートとその加水分解物のグッピーとアサリにおける生物濃縮性と代謝
- An Efficient Synthesis of 4-Acyl-5-hydroxy-3-methylisoxazoles through an Acyl-Transfer Reaction
- N-アリール-4-カルボキシ-および N-アリール-4-ヒドロキシ-フタルイミド類の構造と根こぶ病防除活性
- A New Synthesis of 5-Allkyl-3-aryl-4-oxazolin-2-ones