A Pharmacokinetic Model for Simulating Drug Concentrations in Tissues or Fluids and Its Application to Antibiotics
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概要
- 論文の詳細を見る
Drugs administered in vivo are transferred directly or indirectly from blood to tissues or fluids, and vice versa. In this paper, we propose a model by which the drug concentration in tissues or fluids can be analyzed simply by using a transfer rate constant and apparent clearance ratio, regardless of the transfer route. By using this model, the concentration-time curves of antibiotics in pleural effusion, burn blister fluid and aqueous humor of human subjects were successfully analyzed.
- 公益社団法人日本薬学会の論文
- 1985-07-25
著者
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坪谷 敦子
Central research Division, Takeda Chemical Industries, Ltd.
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水田 榮治
Central Research Division Takeda Chemical Industries Ltd.
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坪谷 敦子
Central Research Division Takeda Chemical Industries Ltd.
関連論文
- A Method for the Pharmacokinetic Analysis of Serum Cefotiam Levels during Cardiopulmonary Bypass Surgery
- A Pharmacokinetic Model for Simulating Drug Concentrations in Tissues or Fluids and Its Application to Antibiotics
- Preparation of Mean Drug Concentration-Time Curves in Plasma. A Study on the Frequency Distribution of Pharmacokinetic Parameters
- A Simple Linear Model for the Simulation of Plasma Concentration-Time Curves Based on the Two-Compartment Open Model