Preparation of Mean Drug Concentration-Time Curves in Plasma. A Study on the Frequency Distribution of Pharmacokinetic Parameters

概要

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A study on the frequency distribution of various pharmacokinetic parameters was conducted using pharmacokinetic data based on human blood samples obtained after administration of three cephalosporin derivatives. The results indicated that pharmacokinetic parameters k_a, k_e, V, α, β, k_<12>, k_<21>, V_1,V_d and Cl followed lognormal distribution curves rather than normal distribution curves. Thus, in the case of a one-compartment open model, it was demonstrated that mean plasma concentration-time curves could be prepared more precisely by use of the geometrical mean values of V, k_e and k_a. In the case of a two-compartment open model, the use of the geometrical mean values of V_1,α, β and k_e rather than those of V_1,k_<12>, k_<21> and k_e was considered to be preferable in view of the reliability of the rate constants α, β, k_<12> and k_<21>.
公益社団法人日本薬学会の論文
1985-04-25