A Simple Linear Model for the Simulation of Plasma Concentration-Time Curves Based on the Two-Compartment Open Model

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概要

• 論文の詳細を見る

• A new in vitro model has been elaborated for the simulation of plasma concentration curves based on the two-compartment open model. The new method consists of a procedure in which vessels containing water or an aqueous solution of a drug are simply connected in a line and the contents are made to flow at a constant rate from one side to the other. The model is expected to be useful for the study of, for example, the in vitro antibacterial activity of antibiotics whose concentrations change according to the two-compartment open model.

• 公益社団法人日本薬学会の論文
• 1984-03-25

著者

• 水田 榮治

  Central Research Division Takeda Chemical Industries Ltd.

関連論文

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• A Pharmacokinetic Model for Simulating Drug Concentrations in Tissues or Fluids and Its Application to Antibiotics
• Preparation of Mean Drug Concentration-Time Curves in Plasma. A Study on the Frequency Distribution of Pharmacokinetic Parameters
• A Simple Linear Model for the Simulation of Plasma Concentration-Time Curves Based on the Two-Compartment Open Model

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