Optical Resolution and Determination of Absolute Configuration of Nipradilol
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概要
- 論文の詳細を見る
It was confirmed that the title compound, a new antihypertensive drug, consists of four optical isomers : two diastereomers and their enantiomers. Separation of the diastereomers was effected by recrystallization. Optical resolution of the enantiomers was carried out by repeated recrystallization of their diastereomeric salts with (+)-or (-)-2-[1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl] acetoxy-2-phenylacetic acid or by high performance liquid chromatography of the L-menthoxyacetyl derivatives. The absolute configurations of the separated isomers were determined on the basis of the circular dichroism spectra and proton nuclear magnetic resonance spectra.
- 公益社団法人日本薬学会の論文
- 1985-07-25
著者
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白土 正三
Tokyo Research Laboratories, Kowa Co., Ltd.,
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村松 豊二郎
Fuji Research Laboratories, Kowa Co., Ltd.,
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村松 豊二郎
Tokyo Research Laboratories, Kowa Co., Ltd.
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吉村 三夫
Tokyo Research Laboratories, Kowa Co., Ltd.
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吉村 三夫
Tokyo Research Laboratory Kowa Co. Ltd.
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大川 泰
Tokyo Research Laboratories Kowa Co., Ltd.,
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白土 正三
Tokyo Research Laboratories Kowa Co. Ltd.
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大川 泰
Tokyo Research Laboratories Kowa Co. Ltd.
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米田 道明
Tokyo Research Laboratories Kowa Co. Ltd.
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村松 豊二郎
Fuji Research Laboratories Kowa Co. Ltd.
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