Kinetics on Uptake of Drugs in Goldfish. IV. Contribution of the Stationary Layer to Drug Absorption from the Gill

概要

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The contribution of the stationary layer to the absorption of benzoic acid, salicylic acid, phenol and p-aminoethylbenzoate from the gills of goldfish was estimated by kinetic analysis of the relationship between perfused flow to the gills and the drug absorption rate. The changes in the absorption rate constant increased as the perfusion velocity increased. A double combination model consisting of an aqueous diffusion layer in the perfusing solution and the diffusion layer on the gill membranes was used to analyze drug absorption from the membranes. Even though the molecular weights of these drugs are similar, there were variations in the permeability coefficients of the drugs through the aqueous diffusion layers, suggesting that drug absorption from the gills cannot be explained simply in terms of a static diffusion layer in the perfusing solution.
社団法人日本薬学会の論文
1979-06-25