Studies on Oxidized Starch Sulfates for Medical Purposes. V. Investigation on the Complex of Pepsin with Sulfates of Oxidized Starch and its Reduced Products.
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概要
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It was confirmed that the complex of pepsin with ROS-S and heparin is formed in an acid solution (pH 1.5〜4.4) and that the complex is dissociated at the pH above 5.2. The isolated complex has no proteolytic activity, but it was almost completely recovered by removing ROS-S or heparin as the barium salt or protamine complex. It was confirmed that the inhibitory action of polysaccharide sulfates on proteolytic action of pepsin is caused by the formation of inactive complex of pepsin with the sulfates.
- 公益社団法人日本薬学会の論文
- 1962-03-25
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関連論文
- Studies on Oxidized Starch Sulfates for Medical Purposes. II. Anticoagulant Activity of Sulfates of Oxidized Starch and its Derivatives.
- Studies on Oxidized Starch Sulfates for Medical Purposes. I. Synthesis of Sulfates of Oxidized Starch and its Derivatives.
- Studies on Oxidized Starch Sulfates for Medical Purposes. V. Investigation on the Complex of Pepsin with Sulfates of Oxidized Starch and its Reduced Products.
- Studies on Oxidized Starch Sulfates for Medical Purposes. IV. Protective Effect of Sulfates of Oxidized Starch and its Reduced Products on Experimental Peptic Ulceration.
- Studies on Oxidized Starch Sulfates for Medical Purposes. III. Inhibition of the Proteolytic Action of Pepsin by Sulfates of Oxidized Starch and its Reduced Products.