Syntheses of Allied Compounds of Lupine Alkaloids. III. Synthesis of 3,6-Dioxo-1H, 3H, 6H-pyrano [3,4,5-i, j] quinolizine.

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概要

• 論文の詳細を見る

• 2-Cyanomethyl-3-methoxymethylpyridine and ethyl (3-methoxymethyl-2-pyridyl) acetate were prepared from ethyl 2-methylnicotinate. Condensation of these compounds with diethyl ethoxymethylenemalonate afforded 1,3-bis (ethoxycarbonyl)-9-methoxymethyl-4-oxo-4H-quinolizine and 1-cyano-3-ethoxycarbonyl-9-methoxymethyl-4-oxo-4H-quinolizine. The ethoxycarbonyl group in these compounds was saponified and further decarboxylated on being heated with hydrochloric acid. A more drastic condition easily afforded 3,6-dioxo-1H, 3H, 6H-pyrano [3,4,5-i, j] quinolizine.

• 公益社団法人日本薬学会の論文
• 1959-03-20

著者

• 佐藤 義信

  Takamine Research Laboratory Sankyo Co. Ltd.

• 佐藤 義信

  Takamine Research Laboratory, Sankyo Co., Ltd.

関連論文

• Syntheses of 2-Hydroxymethylnicotinic Acid Lactone, 2-Hydroxymethylpyridine-3-acetic Acid Lactone, and Some of their Derivatives
• Syntheses of Allied Compounds of Lupine Alkaloids. V. Synthesis of 9-Azahexahydrojulolidine
• Synthesis of 5-Hydroxymethylquinoline-4-carboxylic Acid Lactone.
• Syntheses of Allied Compounds of Lupine Alkaloids. IV. Synthesis and Hydrogenation of 4-Oxo-4H-quinolizine Derivatives.
• Syntheses of Allied Compounds of Lupine Alkaloids. III. Synthesis of 3,6-Dioxo-1H, 3H, 6H-pyrano [3,4,5-i, j] quinolizine.
• Synthesis of 3-Oxo-10a, 1-dihydropyrano [3,4,5-i, j]-6-oxoquinolizine
• The Synthesis of Lupine Alkaloids. II. The Synthesis of 1-(α-Piperidyl) quinolizidine.
• Lupinアルカロイドの合成(第1報) : Sparteine新異性体の合成
• The Migration of Benzyl Group from Nitrogen to the Carbon in the Methyl Group of α-and γ-Picolines.

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