Studies on Naphthyridines. I. Synthesis of 1,6-Naphthyridine.
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概要
- 論文の詳細を見る
A new synthetic process is described for building up the pyridine ring by the utilization of an active methyl group and a carboxyl adjacent to it in the pyridine ring. The reaction of ethyl 2-methylnicotinate and formaldehyde (or acetaldehyde) gave a lactone which was led to an amide, and its oxidation gave 5-hydroxy-1,6-naphthyridine. 1,6-Naphthyridine and 7-methyl-1,6-naphthyridine were synthesized from their 5-hydroxy derivatives via the chloro and hydrazino compounds. Methyl-1,6-naphthyridine N-oxide obtained by the Skraup reaction of 4-amino-2-picoline 1-oxide was established as the 5-methyl derivative.
- 公益社団法人日本薬学会の論文
- 1958-06-20
著者
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池川 信夫
Iwaki Meisei University
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池川 信夫
Rikagaku Kenkyusho (the Institute Of Physical And Chemical Research)
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池川 信夫
Institute of Applied Microbiology, University of Tokyo
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池川 信夫
Institute Of Applied Microbiology University Of Tokyo
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