Design and Racemic Synthesis of Conformationally Restricted Carbocyclic Pyrimidine Nucleoside Analogs Based on the Structure of the L-Nucleoside Residue in Heterochiral DNA
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概要
- 論文の詳細を見る
Carbocyclic pyrimidine nucleoside analogs which have restricted glycosidic conformation at _X≈180° were designed, based on the conformational features of the L-nucleotide residue in heterochiral DNA, and synthesized. The synthesis of (±)-carbocyclic 6,6'-O-cyclo-2'-deoxyuridine was achieved via bromination and subsequent intramolecular cyclization of carbocyclic 6'β-hydroxy-2'-deoxyuridine. (±)-Carbocyclic 6,6'-O-cyclo-2'-deoxycytidine was synthesized from protected carbocyclic 6,6'-O-cyclo-2'-deoxyuridine via the 4-triazole intermediate.
- 社団法人日本薬学会の論文
- 1998-03-15
著者
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Otake Toru
Prefectural Institute Of Public Health
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Akagi Masao
Osaka University Of Pharmaceutical Sciences
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Urata Hidehito
Osaka University of Pharmaceutical Sciences
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MIYAGOSHI Hidetaka
Osaka University of Pharmaceutical Sciences
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KAKUYA Hitoshi
Osaka University of Pharmaceutical Sciences
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TOKUMOTO Hideki
Osaka University of Pharmaceutical Sciences
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KAWAHATA Takuya
Prefectural Institute of Public Health
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Urata Hidehito
Osaka College Of Pharmacy
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