Synthesis and Antitumor Activity of Novel Benzophenone Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Novel benzophenone derivatives were synthesized and screened for cytotoxic and antitumor activity. Friedel-Crafts condensation was employed to construct the benzophenone skeleton. Among the compounds synthesized, morpholino and thiomorpholino benzophenones 3a-d exhibited potent cytotoxic activity against P388 murine leukemia and PC-6 human lung carcinoma cells in vitro, and compounds 3a, 3c, and 3j, when administered intraperitoneally, showed significant antitumor activity against the malignant ascites caused by intraperitoneal inoculation of P388 cells in mice.
- 公益社団法人日本薬学会の論文
- 1997-09-15
著者
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KUMAZAWA Eiji
New Product Research Laboratories IV, Daiichi Pharmaceutical Co., Ltd.
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Kumazawa E
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Kumazawa Eiji
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Ejima A
Medicinal Chemistry Research Laboratory Daiichi Pharmaceutical Co. Ltd.
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HIROTANI Kenji
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.
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EJIMA Akio
New Product Research Laboratories IV, Daiichi Pharmaceutical Co., Ltd.,
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Ishii M
Department Of Physical Chemistry Graduate School Of Pharmaceutical Sciences Chiba University
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Mitsui Ikuo
New Product Research Laboratories Iv Daiichi Pharmaceitucal Co. Ltd.
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Hirotani K
Discovery Research Laboratory Daiichi Pharmaceutical Co. Ltd.
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KAWAGOE Keiichi
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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BURFORD S.
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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MIWA Tamotsu
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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Burford S.
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Miwa Tamotsu
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Kawada K
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Burford S.Clifford
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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