Synthesis and Biological Evaluation of Alkyl, Alkoxy, Alkylthio, or Amino-Substituted 2,3-Dihydro-1,5-benzothiazepin-4(5H)-ones
スポンサーリンク
概要
- 論文の詳細を見る
2,3-Dihydro-1,5-benzothiazepin-4(5H)-ones substituted with an alkyl, alkoxy, alkylthio, hydroxy, or amino group on the fused benzene ring of the 1,5-benzothiazepine skeleton were synthesized and their vasodilating, antihypertensive, and platelet aggregation-inhibitory activities were investigated. (-)-cis-3-Acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-8-methyl-2-(4-methylphenyl)-1,5-benzothiazepin-4(5H)-one ((-)-13e) was selected for further studies as a potent inhibitor of platelet aggregation.
- 公益社団法人日本薬学会の論文
- 1997-06-15
著者
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Nagao T
(present Address)department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences Univer
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OKAMURA Kimio
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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DATE Tadamasa
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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Sasaki H
Biological Research Laboratory:tanabe Seiyaku Co. Ltd.
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TAKEDA MIKIO
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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Sasaki Haruhiko
Biological Research Laboratory:tanabe Seiyaku Co. Ltd.
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Takeda Mikio
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
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Odawara A
Tanabe Seiyaku Co. Ltd. Saitama Jpn
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Murata S
Biological Research Laboratory:tanabe Seiyaku Co. Ltd.
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Okamura Kimio
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
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Date Tadamasa
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
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Date Tadamasa
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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Inoue Hirozumi
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
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Otsuka Hisao
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
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Nagao Taku
(present Address)department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences Univer
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NARITA HIROSHI
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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KONDA Mikihiko
Organic Chemistry Research Laboratory
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HASHIYAMA Tomiki
Organic Chemistry Research Laboratory
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WATANABE AKishige
Organic Chemistry Research Laboratory
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GAINO Mitsunori
Organic Chemistry Research Laboratory
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TAKAHASHI Kaoru
Organic Chemistry Research Laboratory
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MURATA Sakae
Biological Research Laboratory
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ODAWARA AKio
Biological Research Laboratory
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Konda M
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
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Watanabe Akishige
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
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Hashiyama Tomiki
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
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Gaino Mitsunori
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
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Narita Hiroshi
Biological Research Laboratory:tanabe Seiyaku Co. Ltd.
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Takahashi Kaoru
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
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MURATA Sakae
Biological Research Laboratories, Tauabe Seiyaku Co., Ltd.
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TAKEDA Mikio
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co. Ltd.
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