Synthesis of 2-Phenylthiazolidine Derivatives as Cardiotonic Agents. V. : Modification of the Thiazolidine Moiety of 2-(Phenylpiperazinylalkoxyphenyl)thiazolidine-3-thiocarboxamides and the Corresponding Carboxamides(Medeicinal Chemistry,Chemical)

概要

論文の詳細を見る
The carba (2) and oxa analogues (3) of 2-(phenylpiperazinylalkoxyphenyl)thiazolidine-3-carboxamide (1, Y=O) and -thiocarboxamide (1, Y=S) were synthesized and tested for cardiotonic activity. These analogues (2 and 3) were prepared from the aldehydes (4) through several intermediates (7,10, and 13). In a series of the N-methylcarboxamides, positive inotropic activity in anesthetized dogs decreased in the following order: the thiazolidine (1a)≫oxazolidine (3a)>pyrrolidine (2a). In the corresponding thiocarboxamide series, however, the oxazolidine (3b) was the most potent, followed by the thiazolidine (1b) and the pyrrolidine (2c).
公益社団法人日本薬学会の論文
1987-08-25