Improved Scalable Syntheses of Mono- and Bis-Urethane Derivatives of Ornithine

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概要

• 論文の詳細を見る

• In the search for a practical route to ornithine bisurethane derivatives useful for peptide synthesis, we elaborated the simple and efficient (86% yield) synthesis of N^ε-tert-butoxycarbonyl-L-ornithine copper(II) complex(1). This served as substrate for obtaining N^ε-tert-butoxycarbonyl-L-ornithine (2), N^α-benzyloxycarbonyl-N^ε-tert-butoxycarbonyl-L-ornithine (3) and N^α-(9-fluorenyl)methoxycarboiiyl-N^ε-tert-butoxycarbonyI-L-ornithine (4). These were synthesized in 94-95% yields and with a purity above 99%.

• 公益社団法人日本薬学会の論文
• 2001-09-01

著者

• Rzeszotarska B

  Institute Of Chemistry University Of Opole

• WIEJAK Stanislaw

  Laboratory of Chemistry, Technical University of Opole

• MASIUKIEWICZ Elzbieta

  Department of Organic Chemistry, University of Opole

• RZESZOTARSKA Barbara

  Department of Organic Chemistry, University of Opole

• Rzeszotarska Barbara

  Department Of Organic Chemistry University Of Opole

• Wiejak Stanislaw

  Laboratory Of Chemistry Technical University Of Opole

• Masiukiewicz E

  Institute Of Chemisty University Of Opole

• Masiukiewicz Elzbieta

  Department Of Organic Chemistry University Of Opole

関連論文

• The Synthesis, Structure and Properties of N-Acetylated Derivatives of Ethyl 3-Amino-1H-pyrazole-4-carboxylate
• Synthesis, Structure and Properties of N-Acetylated Derivatives of Methyl 5-Amino-1H-[1,2,4]triazole-3-carboxylate
• Improved Scalable Syntheses of Mono- and Bis-Urethane Derivatives of Ornithine
• The Molecular and Crystal Structure of tert-Butyl N^α-tert-Butoxycarbonyl-_L-(S-trityl)cysteinate and the Conformation-Stabilizing Function of Weak Intermolecular Bonding
• A Large Scale Synthesis of Mono- and Di-urethane Derivatives of Lysine
• Convenient High Yielding Gram Scale Solution Synthesis of Methionine-Enkephalin
• Synthesis of Peptides with α, β-Dehydroamino Acids. XIII Photoisomerization of Ac-(Z)-Δ-Phe-NHMe : Ac-(E)-ΔPHe-NHMe

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