A Highly Diastereoselective Pinacol Coupling Reaction of Aldehydes and Ketones Using Low-Valence Niobium Generated from Nb(V)
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概要
- 論文の詳細を見る
A simple method for the diastereoselective synthesis of racemic 1,2-diol mediated by low-valence niobium generated in situ is described. A 1,4-dioxane-toluene solvent system was found to be essential to achieve higher selectivities and to prevent other reactions of pinacols, such as deoxygenation and acetal formation. Aromatic aldehydes and ketones were converted to the corresponding pinacols with up to 97 and 85% de, respectively.
- 公益社団法人日本薬学会の論文
- 2004-02-01
著者
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Nishida Atsushi
Graduate School Of Pharmaceutical Sciences Chiba University
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Arai S
Graduate School Of Pharmaceutical Sciences Chiba University
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Arai Shigeru
Graduate School Of Pharmaceutical Sciences Chiba University
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SUDO Yukinori
Graduate School of Pharmaceutical Sciences, Chiba University
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Sudo Yukinori
Graduate School Of Pharmaceutical Sciences Chiba University
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