Penicillamine Selenotrisulfide as a Selenium-Source in Mice
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概要
- 論文の詳細を見る
In this paper, we compared the bioavailability of penicillamine selenotrisulfide (PenSSeSPen) with the authentic selenium-source compound, selenite. When PenSSeSPen was orally administered to selenium-deficient mice for 7 days, selenium contents of blood, liver and heart significantly increased as well as selenite. In addition, when PenSSeSPen-supplemented diet was fed to 3-week old mice for 7 weeks, selenium contents of selected organs were almost the same as those of selenite, and hepatic cellular glutathione peroxidase (GPx) activity was also observed. These facts evidently indicate that PenSSeSPen, a totally foreign selenium compound, serves as a selenium-source compound.
- 公益社団法人日本薬学会の論文
- 2004-08-01
著者
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Haratake Mamoru
Graduate School Of Biomedical Sciences Nagasaki University
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Haratake Mamoru
長崎大学 医歯薬総研究
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Haratake Mamoru
長崎大学 大学院生命医科学
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Nakayama Morio
Graduate School Of Biomedical Sciences Nagasaki University
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Ono Masahiro
Graduate School Of Biomedical Sciences Nagasaki University
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Nakayama Morio
Graduate School Of Biomedical Sciences Nagasaki Univ.
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Ono Masahiro
Graduate School Of Advanced Sciences Of Matter Hiroshima University
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Haratake Mamoru
Graduate School Of Biomedical Sciences Nagasaki Univ.
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Ono Masaji
Graduate School of Biomedical Sciences, Nagasaki University
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