Neuroprotective Effects of Bak Foong Pill in 1-Methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-Induced Parkinson's Disease Model Mice(Medicinal Chemistry)
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概要
- 論文の詳細を見る
Neuroprotective effects of estrogen and estrogen-like chemicals on neurodegenerative diseases, especially Parkinson's disease, have been well established. In the present study, we compared the effects of Bak Foong Pill (BFP), a well-known gynaecological tonic in China, and 17β-estradiol, on dopamine transporter (DAT) and tyrosine hydroxylase (TH) gene expression patterns in ovariectomized, 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-induced Parkinson's disease (PD) model mice, using multiplex reverse transcription-polymerase chain reaction (RT-PCR). MPTP, a specific dopaminergic neurotoxin, significantly decreased DAT and TH mRNA levels in the striatum, midbrain and cerebellum, but not the cortex, of C57BL/6 mice. However, MPTP-challenge with BFP pretreatment demonstrated reduced neurotoxicity, with DAT and TH mRNA levels either not affected by MPTP or affected to a significantly lesser extent in the midbrain and striatum as compared to the MPTP treated controls. 17β-estradiol treatment prevented MPTP-induced reduction of DAT expression in striatum and midbrain, but failed to alter TH expression. These results suggest that BFP is able to protect dopaminergic neurons against MPTP-induced neuronal damage in a mechanism that is different from the protective effect of estrogen.
- 社団法人日本薬学会の論文
- 2004-08-01
著者
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Rowlands Dewi
Epithelial Cell Biology Research Center Department Of Physiology Faculty Of Medicine The Chinese Uni
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CHUNG Yiu
Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese
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CHAN Hsiao
Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese
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LIU Bin
Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese
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XIE Jun
Department of Physiology, Medical College, Qingdao University
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GOU Yu
Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese
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LEUNG Ching
Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese
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Gou Yu
Epithelial Cell Biology Research Center Department Of Physiology Faculty Of Medicine The Chinese Uni
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Chan Hsiao
Epithelial Cell Biology Research Center Department Of Physiology Faculty Of Medicine The Chinese Uni
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Chung Yiu
Epithelial Cell Biology Research Center Department Of Physiology Faculty Of Medicine The Chinese Uni
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Liu Bin
Epithelial Cell Biology Research Center Department Of Physiology Faculty Of Medicine The Chinese Uni
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Xie Jin
Department Of Physiology Medical College Qingdao University
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Chan Hsiao
Epithelial Cell Biology Research Center
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Leung Ching
Epithelial Cell Biology Research Center Department Of Physiology Faculty Of Medicine The Chinese Uni
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劉 斌
名古屋大学大学院博士課程 工学研究科 土木工学専攻
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Liu B
Genomics Inst. Chinese Acad. Sci. Beijing Chn
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