Effects of Bak Foong Pill on Blood Coagulation and Platelet Aggregation
スポンサーリンク
概要
- 論文の詳細を見る
The effects of Bak Foong Pill (BFP, also known as Bai Feng Wan), a preparation of crude drugs in wide clinical use for treatment of gynecological disorders, on blood coagulation and platelet aggregation were investigated. The anticoagulant effect of BFP was evaluated by using thrombin time (TT), prothrombin time (PT), and activated partial thromboplastin time (APTT) assays. Results showed that BFP 70% ethanol extract (BFP-E-ext) significantly prolonged the TT in a dose-dependent manner with values of 17.6, 38.3, and 50.4s at concentrations of 4.0, 6.0, and 12.0mg/ml, respectively. Whereas, the BFP-E-ext did not show significant prolonging effect in PT and APTT assays. The results suggest that the anticoagulant effect of BFP is mediated by directly blocking thrombin, the key enzyme in the blood coagulation cascade. BFP-E-ext significantly inhibited platelet aggregation induced by collagen and adenosine diphosphate (ADP) with inhibition percentages of 74 and 52% at a concentration of 6.0mg/ml, respectively, whereas, it exhibited a weak inhibitory activity on platelet aggregation induced by archidonic acid (AA). Comparing to BFP-E-ext, the effects of BFP aqueous extract (BFP-W-ext) on both anticoagulant and antiplatelet activities were significantly less potent. Moreover, the effects of the 26 ingredients of BFP on blood coagulation and platelet aggregation were separately evaluated with 19 ingredient herbs exhibiting anticoagulant effect and 10 exhibiting antiplatelet effect. The anticoagulant and antiplatelet effects of BFP were collectively demonstrated by in vivo assays showing prolonged bleeding times after BFP treatment for two weeks. The results of the present studies may provide explanations for beneficial effects of BFP on the circulation and indicate its potential use for cardiovascular diseases.
- 社団法人日本薬学会の論文
- 2003-02-01
著者
-
Rowlands Dewi
Epithelial Cell Biology Research Center Department Of Physiology Faculty Of Medicine The Chinese Uni
-
CHUNG Yiu
Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese
-
CHAN Hsiao
Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese
-
GOU Yu
Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese
-
HO Alice
Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese
-
Gou Yu
Epithelial Cell Biology Research Center Department Of Physiology Faculty Of Medicine The Chinese Uni
-
Chan Hsiao
Epithelial Cell Biology Research Center Department Of Physiology Faculty Of Medicine The Chinese Uni
-
Ho Alice
Epithelial Cell Biology Research Center Department Of Physiology Faculty Of Medicine The Chinese Uni
-
Chung Yiu
Epithelial Cell Biology Research Center Department Of Physiology Faculty Of Medicine The Chinese Uni
-
Chan Hsiao
Epithelial Cell Biology Research Center
関連論文
- Involvement of cystic fibrosis transmembrane conductance regulator (CFTR) in the pathogenesis of hydrosalpinx induced by Chlamydia trachomatis infection
- Effect of Sodium Ferulate on Human Colonic Anion Secretion and the Underlying Signaling Mechanism(Pharmacology)
- Neuroprotective Effects of Bak Foong Pill in 1-Methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-Induced Parkinson's Disease Model Mice(Medicinal Chemistry)
- Effects of Bak Foong Pills and Menoease Pills on White Blood Cell Distribution in Old Age Female Rats (Miscellaneous)
- Effect of Bak Foong Pills on Exocrine Pancreatic-Bile Secretion(Pharmacology)
- Cardiovascular Protective Effects of Traditional Chinese Medicine Bak Foong Pills in Spontaneously Hypertensive Rats(Pharmacology)
- Effect of Bak Foong Pills on Enhancing Dopamine Release from the Amygdala of Female Rats
- Effects of Bak Foong Pill on Blood Coagulation and Platelet Aggregation
- Cellular Signaling Mechanisms Underlying Pharmacological Action of Bak Foong Pills on Gastrointestinal Secretion
- Enhanced Epithelial Na^+ Channel (ENaC) Activity in Mouse Endometrial Epithelium by Upregulation of γENaC Subunit
- Hydrosalpinx Fluid and in vitro Mouse Embryo Development