Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes
スポンサーリンク
概要
- 論文の詳細を見る
The effects of different alpha-1 adrenoceptor blockers on the urethra and the cardiovascular system were evaluated using an in vivo isovolumetric intra-urethral pressure model in New Zealand white rabbits. The urethra of anesthetized male rabbits was cannulated through the bladder and secured at the vesico-urethral junction. The distal side of urethra under the pubic bone was also closed to allow measurement of the intra-urethral pressure. Both the intra-urethral pressure and the femoral arterial pressure were monitored. The effects of five different alpha-1 adrenoceptor blockers on the increases in both the intra-urethral pressure and blood pressure induced by phenylephrine were then examined. The inhibition rate of the alpha-1 adrenoceptor blockers prazosin, bunazosin, terazosin, alfuzosin and tamsulosin on the increase in intraurethral pressure caused as a result of contraction by phenylephrine was 87.5±4.5% (mean±S.E.), 88.0±7.2%, 86.2±6.2%, 81.4±4.8% and 92.5±5.0% respectively. The potency ranking of these alpha-1 adrenoceptor blockers was tamsulosin>bunazosin>prazosin>terazosin>alfuzosin. Their inhibition rate of the arterial pressure increase induced by phenylephrine was 81.9±5.0%, 86.2±5.9%, 76.0±6.0%, 63.6±5.7% and 58.0±5.2% respectively, with a potency ranking of bunazosin>prazosin>terazosin>alfuzosin>tamsulosin. We therefore conclude that the alpha-1 adrenoceptor blockers bunazosin and prazosin have a more potent action on both the urethra and the vascular system. However, tamsulosin and alfuzosin displayed a marked blockade of the increased urethral pressure induced by phenylephrine, with much less of a blockade of arterial pressure. In the present study, tamsulosin has been shown to be the most sensitive and powerful of the alpha-1 adrenoceptor blockers on urethral smooth muscle.
- 日本平滑筋学会の論文
著者
-
Yamaguchi Takanori
Department Of Applied Chemistry And Chemical Engineering Faculty Of Engineering Yamaguchi University
-
Yamaguchi Takanori
Department Of Urology Fukuoka City Medical Center For Sick Children And Infectious Diseases
-
Osada Yukio
Department Of Urology Miyazaki Medical College
-
Osada Yukio
Department Of Urology Miyazaki University School Of Medicine
-
Nagano Masashi
Department Of Urology Miyazaki University School Of Medicine
-
Nagano Masashi
Department Of Theriogenology Faculty Of Veterinary Medicine Hokkaido University
関連論文
- Photochromic Properties of Diarylethene Derivatives Having Benzofuran and Benzothiophene Rings Based on Regioisomers
- Thermally Irreversible Photochromic Systems. Reversible Photocyclization of 2-(1-Benzothiophen-3-yl)-3-(2 or 3-thienyl)maleimide Derivatives
- Substituent Effects of 1,2-Bis (2-thienyl) perfluorocyclopentenes
- Genetic Polymorphisms of CYP2A6 and CYP2E1 with Tobacco Smoking is not Associated with Risk of Urothelial Cancer
- Retroperitoneal bronchogenic cyst: Report of a case and literature review
- cDNA Sequencing and Expression of Rat Mast Cell Tryptase^1
- Postoperative UFT Adjuvant and the Risk Factors for Recurrence in Renal Cell Carcinoma: A Long-Term Follow-Up Study
- Expression and distribution of OCTN2 in mouse epididymis and its association with obstructive azoospermia in juvenile visceral steatosis mice
- Photochromism of a Chiral Cyclohexane Having Two Diarylethene Chromophores.A Large Optical Rotation Change
- Membrane Phenomena in Nonisothermal Systems : Part 3. Thermal Membrane Potential across Various Hydrophobic Anion-Exchange Membranes with 10 and 14% Divinylbenzene
- Membrane Phenomena in Nonisothermal Systems: Part 2. Effect of Hydrophobicity of Ion-Exchange Groups of Anion-Exchange Membranes on Thermoosmosis
- Synthesis and Physical Property of a Novel Diarylethene Derivative Having a Chryso[b]thiophene Ring
- Triangular Platinum(II) Cluster Complexes and Cluster Core Transformation From Square-Planar to Triangular Type
- Photochromic Reactions of Two Azobenzene Chromophores in a Chiral Cyclohexane Moiety
- Radiation-Induced Coloration of Photochromic Dithienylethene Derivatives
- Usefulness of oral wash specimens for detecting Chlamydia trachomatis from high-risk groups in Japan
- Bacteria of preoperative urinary tract infections contaminate the surgical fields and develop surgical site infections in urological operations
- The Effect of Ovarian Status and Follicular Diameter on Maturational Ability of Domestic Cat Oocytes
- Comparison Between Laparoscopy and MRI for the Non-Palpable Testis
- Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes
- Antioxidant Activities of Phenothiazines and Related Compounds : Correlation between the Antioxidant Activities and Dissociation Energies of O-H or N-H Bonds
- IN VITRO MATURATION, FERTILIZATION AND SUBSEQUENT DEVELOPMENTAL POTENTIAL OF BOVINE OOCYTES WITH DIFFERENT MORPHOLOGICAL CHARACTERISTICS
- Antioxidant Activities of Phenothiazines and Related Compounds : Correlation between the Antioxidant Activities and Dissociation Energies of O-H or N-H Bonds