[<99m>^Tc]d,1-HM-PAOを用いた局所脳血流シンチグラフィーの基礎的検討と臨床応用

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As [<99m>^Tc]d, 1-HM-PAO passes the blood brain barrier and is retained in the brain cells for several hours, this radiopharmaceutical is expected to be an excellent regional cerebral blood flow (rCBF) tracer. A basic study was carried out on radiopharmaceutical purity of the lipophilic fraction of [<99m>^Tc] d, 1-HM-PAO and data acquisition with the brain SPECT. The radiopharmaceutical was formed to have a high yield (>90 %) by the stannous reduction of <99>^M0/<99m>^Tc generator elute (<35mCi) using a ligand kit. The reduction of lipophilic fraction of [<99m>^Tc] d, 1-HM-PAO was observed with excess of <99m>^TcO_4-, because of scarcity of SnCl_2, as the reductant. Using the high yield (>90%) of lipophilic fraction of [<99m>^Tc]d, 1-HM-PAO, more than 6% of administrated dose of [<99m>^Tc], d, 1-HM-PAO accumulated in the brain. The rapid clearance of [<99m>^Tc] d, 1-HM-PAO from the blood allowed the taking of a clear SPECT image with a low background at 30 min after the injection. Phantom study on data collection showed that the SPECT image had more than 300 counts/pixel (raw data 300k counts/slice) needed to take the brain SPECT haveing quality good enough to detect a cold lesion of 12mmφ. This data acquisition criterion could be applied to the clinical study. In 15 cases of the cerebral vascular disease, all of the stenotic lesions (≧90%) of major cerebral arteries could be detected as hypoperfusion areas with [<99m>^Tc] d, 1-HM-PAO brain SPECT ; however, only 53% of the lesions could be detected as low density areas by a brain X-ray CT. In conclusion, the [<99m>^Tc] d, 1-HM-PAO brain SPECT was useful for detecting abnormalities in the cerebral blood flow.
公益社団法人日本放射線技術学会の論文
1988-07-01

[<99m>^Tc]d,1-HM-PAOを用いた局所脳血流シンチグラフィーの基礎的検討と臨床応用

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