1. 局所脳血流測定における技術的問題点 : 脳神経核医学検査の技術的問題点 : 第45回総会シンポジウム

概要

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Regional cerebral blood flow (rCBF) has been noninvasively estimated by measuring the radioactive inert gas (Xe-133) clearance rate of the fast (gray matter) compartment of the brain. However, there are some technical problems in the Xe-133 clearance method as follows : (1) statistical errors due to low accumulation of Xe-133 in the brain, (2) relatively high radioactivities in the blood, which requires the correction with the measurement of radioactivities in the expiratory gas, and (3) inappropriateness of the mathematical equation for calculating rCBF. Since 1974, we have studied for solving the above problems. We have developed a super high sensitivity collimator for minimizing the statistical errors and a method for eliminating air passage artifact. Also, we have studied about the limitation of the mathematical equation for calculating rCBF. In this report, we summarize these problems in the measurement of rCBF by the Xe-133 clearance method.
公益社団法人日本放射線技術学会の論文
1989-10-01