筋弛緩剤のアクトミオシン系への効果とイオン強度と温度について

概要

論文の詳細を見る
Effect of Temperature and Ionic Strength on the Interaction of Actomyosin with Some Relaxing Agents. It was found that the action of the relaxing agent formamide (Watanabe et al., 1963) on the ATP-actpmyosin system greatly depends upon the ionic strength and temperature : at very low ionic strength, formamide causes only a slight clearing response of actmyosin and gives a small inhibition of its ATP-ase activity (Fig. 1). The action of formamide (FA) was more pronounced at low temperature (Table I). However, the action of the chelating agent glycolethertetraacetic acid (EGTA) was not affected significantly by ionic strength and temperature in the ranges tested (Table I). The mechanism of the action of these two muscle relaxing agents is considered to be different. Apart from the differences stated above, the effect of Ca was entirely different among the two : whereas addition of Ca^<++> induced superprecipitation in the presence of EGTA, Ca did not give any effect on formamide-induced clearing. This work was supported bya grant-in-aid from the Muscular Dystrophy Associations of America, Inc.
1963-02-15