Molecular- and Immuno-histochemical Study on Expressions of Vasopressin and Oxytocin Genes Following Sodium Loading : Endocrinology

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概要

• 論文の詳細を見る

• We investigated the effects of drinking hypertonic saline on expressions of vasopressin (AVP) and oxytocin (OXT) genes in neurosecretory neurons of the supraoptic (SON) and the paraventricular (PVN) nuclei in rats with the oligonucleotide-mRNA in situ hybridization and the immunohistochemical avidin-biotin-peroxidase complex (ABC) methods. Autoradiographic hybridization signals that indicate the localization of AVP mRNA were significantly increased in the SON 4days after the commencement of the sodium loading, while the signal increase in the PVN was less conspicuous than that in the SON. Signals for OXT mRNA in both the SON and the PVN were rapidly increased and attained to a peak level by the second day after the onset of sodium loading. In the hypothalamic sections adjacent to those used for in situ hybridization, the number of immunoreactive (ir) AVP neurons was decreased in the PVN by day 7. The percentage of heavily stained AVP neurons to all ir-AVP ones was decreased in the SON by day 7. Changes in the number of ir-OXT neurons and the percentage of heavily stained OXT neurons were insignificant. Significant hypertrophy was found in both AVP and OXT neurons in the SON and the PVN after day 2. The present results thus indicate that the AVP and OXT mRNAs are increased by sodium loading. It is probable that supraoptic AVP neurons are more sensitive to changes in extracellular sodium concentration than paraventricular AVP neurons, and that OXT neurons have some physiological role in the water and salt metabolism.

• 社団法人日本動物学会の論文
• 1988-10-15

著者

• Urano Akihisa

  Department Of Regulation Biology Faculty Of Science Saitama University:(present)ocean Research Insti

• Fujiwara M

  Univ. Ryukyus Okinawa Jpn

• SATO Moriyuki

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• Hyodo Susumu

  Department of Physiology, Ocean Research Institute, the University of Tokyo

• Hyodo S

  Univ. Tokyo Tokyo Jpn

• Hyodo S

  Division Of Marine Bioscience Ocean Research Institute The University Of Tokyo

• Hyodo Susumu

  Department Of Biology College Of Arts And Sciences University Of Tokyo

• FUJIWARA MAMORU

  Department of Regulation Biology, Faculty of Science, Saitama University

• Fujiwara Mamoru

  Department Of Regulation Biology Faculty Of Science Saitama University

• Urano Akihisa

  Department Of Regulation Biology Faculty Of Science Saitama University

• Sato M

  Univ. Tokyo Tokyo

• Sato Moriyuki

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Hiraoka Shuichi

  Devision Of Biological Sciences Graduate School Of Science Hokkaido University

関連論文

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• EFFECTS OF ENVIRONMENTAL SALINITY ON SYNTHESIS AND RELEASE OF NEUROHYPOPHYSIAL HORMONES AND C-TYPE NATRIURETIC PEPTIDE IN DOGFISH, TRIAKIS SCYLLIA(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan
• Molecular- and Immuno-histochemical Study on Expressions of Vasopressin and Oxytocin Genes Following Water Deprivation : Endocrinology
• Molecular- and Immuno-histochemical Study on Expressions of Vasopressin and Oxytocin Genes Following Sodium Loading : Endocrinology
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• EFFECTS OF OSMOTIC STIMULATION ON EXPRESSION OF NEUROHYPOPHYSIAL HORMONE GENES IN HOMING CHUM SALMON, Oncorhynchus keta
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