異種免疫抗血清およびリンパ系細胞の組織培養細胞に対する細胞毒作用

概要

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In vitro cytotoxity of xenoimmunized antisera and immune lymphoid cells of rats was investigated. Sensitization of rats was performed with ICR-JCL mice kidney cells. Sera from the recipient animals showed marked cytotoxic action both on the primary cultures of mice kidney cells and on the strained L cells of C3H mice origin. An absorption of antisera with sheep erythrocytes led to a decrease in cytotoxity against primary cultures of target cells. Against the strained L cells, however, such an absorption did not remove the cytotoxity markedly. These observations suggest that mouse has both Forssman and another Forssman-like antigens differing immunologically from the antigens of sheep erythrocytes. No cytotoxic effects of splenic cells obtained from immunized rats observed in our experimental system.
社団法人日本動物学会の論文
1968-03-15