Regulation of the Xmyf-5 and XmyoD Expression Pattern during Early Xenopus Development
スポンサーリンク
概要
- 論文の詳細を見る
In beginning of muscle development, determination is induced in the mesoderm, and then differentiation occurs with accumulation of muscle structural proteins. Mesoderm cells differentiate to many type cells, but the direct signaling activator for muscle determination is still unknown. In this paper we report some of the conditions required for determination of muscle. Muscle determination during Xenopus development was found to be marked by Xmyf-5 and XmyoD expression, but not by expression of Xmyogenin or Xmrf4. Xmyf-5 and XmyoD expression was first detected in the early gastrula stage. Xmyf-5 expression was first detected on the dorsal side, whereas XmyoD was initially expressed on the ventral side. Subsequently, expression of both genes was strongly induced on the dorsal side. The expression of Xmyf-5 and XmyoD did not continue to increase on the ventral side when it was separated from the dorsal side, although muscle originates from the both sides. These findings suggest that a continous increase in expression of both genes require the dorsalizing signal. The mesoderm inducers bFGF and Activin A induced both genes in animal caps, and the inductive activity of Activin A was stronger than that of bFGF. Overexpression of Xbra, a pan-mesoderm marker, alone induced both genes, but weakly. The inductive activity of Xbra was enhanced by co-injection with noggin. This suggests that inhibition of BMP4 by noggin in the mesoderm mediates dorsalizing signal, and may induce the direct dorsalizing activator genes of Xmyf-5 and XmyoD.
著者
-
ASASHIMA Makoto
Department of Biological Sciences, Graduate School of Science, The University of Tokyo
-
Nabeshima Yo-ichi
Department Of Molecular Gemetics National Institute Of Neuroscience Ncnp
-
Takahashi Shuji
Department Of Biosciences Teikyo University
-
Takahashi Shuji
Department Of Life Science(biology) The University Of Tokyo
-
Esumi Eisaku
Department of Molecular Genetics, National Institute of Neuroscience, NCNP
-
Asashima Makoto
Department Of Life Science(biology) The University Of Tokyo:crest Japan Science And Technology Corpo
-
Asashima Makoto
Department Of Biological Science Graduate School Of Science University Of Tokyo
-
Esumi Eisaku
Department Of Molecular Genetics National Institute Of Neuroscience Ncnp
-
Nabeshima Yoichi
Department of Molecular Gemetics, National Institute of Neuroscience, NCNP
関連論文
- OJ-155 The Decrease of Klotho Gene Expression in Kidney of Diabetes Mellitus(Kidney / Renal circulation-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- An increase in superoxide production in klotho mice
- -0156- NOREPINEPHRINE-INDUCED CONTRACTION AND EFFECTS OF VERAPAMIL AND RYANODINE IN ISOLATED AORTIC RINGS FROM TRANSGENIC MICE OVEREXPRESSING Na^+/H^+ EXCHANGER(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- NATURAL ANTIGENIC PEPTIDES OF GASTRIC SIGNET RING CELL CARCINOMAS
- Cytotoxicity of Histocompatibility Leukocyte Antigen-DR8-restricted CD4+ Killer T Cells against Human Autologous Squamous Cell Carcinoma
- Inhibition of Natural Killer Cell Cytotoxicity by Cell Growth-related Molecules
- Screening for novel pancreatic genes from in vitro-induced pancreas in Xenopus
- Fatal acute hepatic failure induced by danazol in a patient with endometriosis and aplastic anemia
- Formation of Actin Filament Networks in Cultured Rat Hepatocytes Treated with DMSO and Glucagon
- Cloning and expression pattern of Xenopus prx-1 (Xprx-1) during embryonic development
- Angiogenesis and Vasculogenesis are Impaired in Precocious Aging Klotho Mouse(Angiogenesis 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Expression of BMP-2,4 Genes during Early Development in Xenopus
- The Zoological Society of Japan 125th Anniversary SymposiumPROCEEDING OF THE 75^ ANNUAL MEETING OF THE ZOOLOGICAL SOCIETY OF JAPAN)
- A Case of Small Pancreatic Ductal Carcinoma Accompanied by Intraductal Mucin-Producing Pancreatic Tumors
- Cloning a novel developmental regulating gene, Xotx5 : Its potential role in anterior formation in Xenopus laevis
- Evidence that far infrared radiation promotes growth of Xenopus laevis
- Immunocytochemical study of activin type IB receptor (XALK4) in Xenopus oocytes
- Global and temporal regulation of gene expression in Xenopus kidney cells in response to presumed microgravity generated by 3D clinostats
- Restricted Expression of Xenopus Midkine Gene during Early Development
- Synthesis and release of activin and noggin by cultured human amniotic epithelial cells
- The Na^+, K^+-ATPase α subunit requires gastrulation in the Xenopus embryo
- Role of the thrombopoietin (TPO)/Mpl system : c-Mpl-like molecule/TPO signaling enhances early hematopoiesis in Xenopus laevis
- Characterization of a gene respondent to clinorotation in Xenopus A6 cells
- Effects of rat Axin domains on axis formation in Xenopus embryos
- Ischemia-Induced Neovascularization is Impared in Klotho-Mutant Mice : Role of Angiogenesis and Vasculogenesis
- Clonal dominance of human autologous cytotoxic T lymphocytes against gastric carcinoma:molecular stability of the CDR3 structure of the TCRαΒ gene
- Blood Cell and Vessel Formation Following Transplantation of Activin-Treated Explants in Xenopus(Molecular and Cell Biology)
- Induction of Cells Expressing Vascular Endothelium Markers from Undifferentiated Xenopus Presumptive Ectoderm by Co-treatment with Activin and Angiopoietin-2(Developmental Biology)
- In vitro induction of the pronephric duct in Xenopus explants
- Troglitazone Improves Endothelial Function and Augments Renal klotho mRNA Expression in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats with Multiple Atherogenic Risk Factors
- Impairment of B lymphopoiesis in precocious aging (klotho) mice
- ROLE OF CXCR4/SDF-1 SIGNALING IN XENOPUS GASTRULATION(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- MODIFICATION OF GENE EXPRESSION BY ACTIVIN-A IN XENOPUS PRESUMPTIVE ECTODERM(Developmental Biology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- T-Cell Receptor Gene Structures of HLA-A26-restricted Cytotoxic T Lymphocyte Lines against Human Autologous Pancreatic Adenocarcinoma
- Midkine Counteracts the Activin Signal in Mesoderm Induction and Promotes Neural Formation^1
- Characterization of myeloid cells derived from the anterior ventral mesoderm in the Xenopus laevis embryo
- Directional migration of neuronal PC12 cells in a ratchet wheel shaped microchamber(CELL AND TISSUE ENGINEERING)
- INDUCTION OF MAXILLOFACIAL CARTILAGE FROM XENOPUS PRESUMPTIVE ECTODERM BY ACTIVIN A(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- INDUCTION OF BLOOD VESSELS FROM UNDIFFERENTIATED XENOPUS EXTODERM (ANIMAL CAP) BY ACTIVIN A(Taxonomy and Systematics,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- EFFECT OF TGF-β ON MORPHOGENESIS IN RAT SALIVARY GLAND-DERIVED RSMG-1 CELLS
- Endoderm differentiation and inductive effect of activin-treated ectoderm in Xenopus
- Cytochalasin B inhibits morphogenetic movement and muscle differentiation of activin-treated ectoderm in Xenopus
- Neural induction in embryos
- Patterns of gene expression in the core of Spemann's organizer and activin-treated ectoderm in Cynops pyrrhogaster
- Activin-treated ectoderm has complete organizing center activity in Cynops embryos
- IN VITRO INDUCTION AND TRANSPLANTATION OF EYE DURING EARLY XENOPUS DEVELOPMENT(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- In vitro induction and transplantation of eye during early Xenopus development
- IN VITRO INDUCTION AND TRANSPLANTATION OF EYEBALL DURING EARLY XENOPUS DEVELOPMENT(Developmental Biology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Electron Microscopical and Histochemical Studies of the Spontaneous Tumors of Xenopus laevis : Cell Biology
- COMPARISON OF INDUCTION DURING DEVELOPMENT BETWEEN XENOPUS TROPICALIS AND XENOPUS LAEVIS(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Determination, induction and pattern formation in early amphibian embryos
- Sequential gene expression durnig pronephric tubule formation in vitro in Xenopus ectoderm
- Tumors in Amphibia
- Xenopus tropicalis as an ideal laboratory animal of Amphibia
- ESTABLISHMENT OF RSMG-2 CELL LINE DERIVED FROM MALE RAT SUBMANDIBULAR GLAND IN SERUM-FREE DEFINED CULTURE
- Chromosome mapping of Xenopus tropicalis using the G- and Ag-bands : Tandem duplication and polyploidization of larvae heads
- Detection of p53 Gene Mutations in Aspiratopm Biopsy Specimens from Suspected Breast Cancers by Polymerase Chain Reaction-Single Strand Conformation Polymorphism Analysis
- Cloning and characterization of the Xenopus laevis p8 gene
- TWO DISTINCT ROLES OF PCP GENES IN XENOPUS GASTRULATION(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Pathological and Immunohistochemical Analyses of Anti-Tumor Effect of 3'-Sulfonoquinovosyl 1'-Monoacylglyceride Extracted from Sea Urchin Intestine on the Human Lung Cancer Cell Line
- Effects of High and Very Low Magnetic Fields on the Growth of Hairy Roots of Daucus carota and Atropa belladonna
- Changes in the adhesive properties of dissociated and reaggregated Xenopus laevis embryo cells
- Onset of competence to respond to activin A in isolated eight-cell stage Xenopus animal blastomeres
- Comparative cytology of stromal tumors of the gastrointestinal tract
- Enhancement of Repositioning Tolerance by Directionally Controlled Shift Selectivity of Speckle-Multiplexed Holograms
- Regulation of the Xmyf-5 and XmyoD Expression Pattern during Early Xenopus Development
- I-2 EMBYROGENESIS OF ALIMENTARY TRACT DUPLICATION AND ENTERIC CYST : CONSIDERATION OF SPLIT NOTOCHORD SYNDROME
- Challenge of overcoming aging-related disorders
- Thiomarinols D. E. F and G, New Hybrid Antimicrobial Antibiotics Produced by a Marine Bacterium; Isolation, Structure, and Antimicrobial Activity
- Multifunctionality of the Activin Molecule(Messages from Comparative Endocrinology: Diverse Hormone Function,Symposium,PROCEEDING OF THE 75^ ANNUAL MEETING OF THE ZOOLOGICAL SOCIETY OF JAPAN)
- A CELL CYCLE REGULATOR, XBtg2 IS REQUIRED FOR XENOPUS NEURAL DEVELOPMENT(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- History and Current Role of the Academic Journal of the Zoological Society of Japan : From Zool. Mag. and Annat. Zool. to Zoological Science(Symposium On the 20^ Anniversary of Publishing Zoological Science,PROCEEDING OF THE 74^ ANNUAL MEETING OF
- Embryonic Induction and Cell Diffierentiation During the Amphibian Development : THE ZOOLOGICAL SOCIETY PRIZE
- Control of the Embryonic Body Plan by Activin during Amphibian Development
- Volatile Plant Constituents Cause Behavioural Changes Ultimately Leading to Death in the Newt (Cynops pyrrhogaster)
- Identification and characterization of Xenopus OMP25
- In vitro control of organogenesis and fundamental embryonic form by the peptide growth factor activin
- Is motoneuronal cell death in amyotrophic lateral sclerosis apoptosis?
- Development of the embryonic kidney
- Problems related to the titratable acidity of TPN solution products and the role of the pharmacist
- Discovery of .ALPHA.-Klotho unveiled new insights into calcium and phosphate homeostasis
- Morphological changes in newt epitheliomas caused by controlled temperature.
- Spontaneous Progressive Skin Papilloma in (NewtsCynops pyrrhogaster)
- Biosynthesis of the neuron-specific enolase (14-3-2 protein) in a cell free system from wheat germ extract directed with poly(A)-containing RNA from rat brain.
- Histological and electron microscopical studies on neoplasia subcutaneously occurring in Xenopus laevis.