Discovery of .ALPHA.-Klotho unveiled new insights into calcium and phosphate homeostasis
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概要
- 論文の詳細を見る
α-Klotho was first identified as the responsible gene in a mutant mouse line whose disruption results in a variety of premature aging-related phenotypes. α-Klotho has been shown to participate in the regulation of parathyroid hormone secretion and trans-epithelial transport of Ca<SUP>2+</SUP> in the choroid plexus and kidney. α-Klotho, acting as a cofactor for FGF23, is also a major regulator of vitamin D biosynthesis and phosphate reabsorption in the kidney. These suggest that α-Klotho is a key player that integrates a multi-step regulatory system of calcium and phosphate homeostasis. Collectively, the molecular function of α-Klotho reveals a new paradigm that may change current concepts in mineral homeostasis and give rise to new insights in this field.<BR><BR>(Communicated by Takao SEKIYA, M.J.A.)
- 日本学士院の論文
著者
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Nabeshima Yo-ichi
Department Of Molecular Gemetics National Institute Of Neuroscience Ncnp
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NABESHIMA Yo-ichi
Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine
関連論文
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